Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
Por:
Salas S, Agut-Quijano T, Rovira-Zurriaga C, Canizo D, Lavarino C and García-Alix A
Publicada:
1 nov 2016
Categoría:
Neurology (clinical)
Resumen:
Introduction. Congenital glioblastoma multiforme represents only 3% of congenital central nervous system tumours and an infratentorial location is unusual.
Case report. A newborn with congenital glioblastoma multiforme with no mutation in the TP53 gene or p53 nuclear immunoreactivity that infiltrated practically the whole brainstem and also invaded supratentorial structures.
Conclusions. As far as we know, only four cases with an infratentorial location have been reported previously, three in the cerebellum and one in the brainstem. The biology of congenital glioblastoma multiforme is not well known and, unlike glioblastoma multiforme in adults and children, mutations in the TP53 gene are uncommon. However, this is not associated with a more favourable prognosis. These observations suggest that specific biological processes underlie fetal glioblastoma multiforme development.
Filiaciones:
Salas S:
Hospital Sant Joan de Deu, Esplugues de Llobregat, Espana
Agut-Quijano T:
Hospital Sant Joan de Deu, Esplugues de Llobregat, Espana
Rovira-Zurriaga C:
Hospital Sant Joan de Deu, Esplugues de Llobregat, Espana
Canizo D:
Hospital Sant Joan de Deu, Esplugues de Llobregat, Espana
Lavarino C:
Hospital Sant Joan de Deu, Esplugues de Llobregat, Espana
García-Alix A:
Hospital Sant Joan de Deu, Esplugues de Llobregat, Espana
Open Access
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