Viral load at diagnosis and influenza A H1N1 (2009) disease severity in children
Por:
Launes-Montana C, García-García JJ, Jordán-García I, Selva L, Rello J and Munoz-Almagro C
Publicada:
1 nov 2012
Ahead of Print:
24 may 2012
Resumen:
To assess viral load at diagnosis (VLAD) as a biomarker of novel influenza disease severity, epidemiologic and clinical data of admitted patients <18 years old with Influenza A H1N1 (2009) infection and respiratory symptoms were prospectively collected in a single pediatric tertiary hospital, from weeks 3051 of 2009. Seventy patients were included. VLAD in children who had symptoms for =5 days was an accurate parameter distinguishing the patients who required mechanical ventilation (MV) from those who did not required it (area under the ROC curve: 0.73; P = 0.03). Having <4.5 log10 copies/ml with =5 days of symptoms was associated with a lower risk of requiring MV.
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