Meta-analysis of the DRD5 VNTR in persistent ADHD
Por:
Klein M, Berger S, Hoogman M, Dammers J, Makkinje R, Heister AJ, Galesloot TE, Kiemeney LA, Weber H, Kittel-Schneider S, Lesch KP, Reif A, Ribase´s M, Ramos-Quiroga JA, Cormand B, Zayats T, Hegvik TA, Jacobsen KK, Johansson S, Haavik J, Mota NR, Bau CH, Grevet EH, Doyle A, Faraone SV, Arias-Va´squez A and Franke B
Publicada:
1 sep 2016
Ahead of Print:
29 jul 2016
Resumen:
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. DRD5, the gene encoding the dopamine receptor D5, was recently confirmed as a candidate gene for ADHD in children through meta-analysis. In this study, we aimed at studying the association of the ADHD-associated variable number tandem repeat (VNTR) polymorphism upstream of DRD5 with adult ADHD. We compiled data from six sites of the International Multicentre persistent ADHD CollaboraTion (IMpACT) and reached N=6979 (3344 cases and 3635 healthy participants), the largest sample investigated so far. We tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts. Our findings provide evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults.
Filiaciones:
Klein M:
Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Human Genetics, Nijmegen, The Netherlands
Berger S:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany
Hoogman M:
Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Human Genetics, Nijmegen, The Netherlands
Dammers J:
Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Human Genetics, Nijmegen, The Netherlands
Makkinje R:
Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Human Genetics, Nijmegen, The Netherlands
Heister AJ:
Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Human Genetics, Nijmegen, The Netherlands
Galesloot TE:
Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands
Kiemeney LA:
Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands
Weber H:
Department of Psychiatry, Psychosomatics and Psychotherapy, IZKF Würzburg, University Hospital of Würzburg, Würzburg, Germany
Kittel-Schneider S:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany
Lesch KP:
ADHD Clinical Research Unit, Division of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
Reif A:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany
Ribase´s M:
Biomedical Network Research Center on Mental Health (CIBERSAM), Institute of Salud Carlos III, Spain
Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain
Department of Psychiatry, University Hospital Vall d?Hebron, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain
Psychiatric Genetics Unit, University Hospital, Vall d?Hebron, Barcelona, Catalonia, Spain
Ramos-Quiroga JA:
Biomedical Network Research Center on Mental Health (CIBERSAM), Institute of Salud Carlos III, Spain
Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain
Department of Psychiatry, University Hospital Vall d?Hebron, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain
Psychiatric Genetics Unit, University Hospital, Vall d?Hebron, Barcelona, Catalonia, Spain
Cormand B:
Department of Genetics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain
Instituto de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Spain
Institute of Biomedicine, University of Barcelona (IBUB), Barcelona, Catalonia, Spain
Zayats T:
K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway
Hegvik TA:
Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Jacobsen KK:
Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Johansson S:
K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Clinical Science, University of Bergen, Bergen, Norway
Haavik J:
Department of Psychiatry, Haukeland University Hospital, Bergen, Norway
Mota NR:
Department of Genetics, Institute of Bioscience, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
ADHD Outpatient Program-Adult Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Bau CH:
Department of Genetics, Institute of Bioscience, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
ADHD Outpatient Program-Adult Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Grevet EH:
Department of Psychiatry, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Doyle A:
Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Stanley Center for Psychiatric Research at the Broad Institute, Cambridge, MA, USA
Faraone SV:
Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA
Arias-Va´squez A:
Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, Nijmegen, The Netherlands
Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, The Netherlands
Franke B:
Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, Nijmegen, The Netherlands.
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