Relationship between depression and frailty in older adults: A systematic review and meta-analysis.
Por:
Soysal P, Veronese N, Thompson T, Kahl KG, Fernandes BS, Prina AM, Solmi M, Schofield P, Koyanagi A, Tseng PT, Lin PY, Chu CS, Cosco TD, Cesari M, Carvalho AF and Stubbs B
Publicada:
1 jul 2017
Ahead of Print:
31 mar 2017
Resumen:
AIM: Depression and frailty are prevalent and burdensome in older age. However, the relationships between these entities are unclear and no quantitative meta- analysis exists. We conducted a systematic review and meta-analysis to investigate the associations between depression and frailty. METHODS: Two authors searched major electronic databases from inception until November-2016 for cross-sectional/longitudinal studies investigating depression and frailty. The strength of the reciprocal associations between frailty and depression was assessed through odds ratios (ORs) adjusted for potential confounders. RESULTS: From 2306 non duplicated hits, 24 studies were included. The overall prevalence of depression in 8023 people with frailty was 38.60% (95% CI 30.07-47.10, I(2)=94%). Those with frailty were at increased odds of having depression (OR adjusted for publication bias 4.42, 95%CI 2.66-7.35, k=11), also after adjusting for potential confounders (OR=2.64; 95%CI: 1.59-4.37, I(2)=55%, k=4). The prevalence of frailty in 2167 people with depression was 40.40% (95%CI 27.00-55.30, I(2)=97%). People with depression were at increased odds of having frailty (OR=4.07, 95%CI 1.93-8.55, k=8). The pooled OR for incident frailty, adjusted for a median of 7 confounders, was 3.72 (95%CI 1.95-7.08, I(2)=98%, k=4), whilst in two studies frailty increased the risk of incident depression with an OR=1.90 (95%CI 1.55-2.32, I(2)=0%). CONCLUSION: This meta-analysis points to a reciprocal interaction between depression and frailty in older adults. Specifically, each condition is associated with an increased prevalence and incidence of the other, and may be a risk factor for the development of the other. However, further prospective investigations are warranted.
Filiaciones:
Soysal P:
Kayseri Education and Research Hospital, Geriatric Center, Kayseri, Turkey
Veronese N:
National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy
Institute of Clinical Research and Education in Medicine (IREM), Padova, Italy
Thompson T:
Faculty of Education and Health, University of Greenwich, London, United Kingdom
Kahl KG:
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
Fernandes BS:
IMPACT Strategic Research Centre, Deakin University School of Medicine, and Barwon Health, Geelong, VIC, Australia
Laboratory of Calcium Binding Proteins in the Central Nervous System, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Prina AM:
Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, Box SE5 8AF, United Kingdom
Solmi M:
Department of Neurosciences, University of Padova, Padova, Italy
Local Health Unit 17, Mental Health Department, Padova, Italy
Schofield P:
Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, United Kingdom
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain
Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5 Pabellón 11, Madrid 28029, Spain
Tseng PT:
Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai's Home, Taiwan
Lin PY:
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan
Institute for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
Chu CS:
Department of Psychiatry, Puli Branch, Taichung Veterans General Hospital, Taiwan
Cosco TD:
MRC Unit for Lifelong Health and Ageing at UCL, 33 Bedford Place, London WC1 B5JU, United Kingdom
Oxford Institute of Population Ageing, University of Oxford, 66 Banbury Road, Oxford, OX2 6PR, United Kingdom
Cesari M:
Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
Carvalho AF:
Translational Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil
Stubbs B:
Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, United Kingdom.
Green Accepted, Green Submitted, Green Published
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