A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
Por:
Jroundi I, Mahraoui C, Benmessaoud R, Moraleda C, Tligui H, Seffar M, El Kettani SE, Benjelloun BS, Chaacho S, Munoz-Almagro C, Ruiz J, Alonso PL and Bassat Q
Publicada:
1 feb 2016
Resumen:
Acute respiratory infections remain the principal cause of morbidity and mortality in Moroccan children. Besides bacterial infections, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are prominent among other viruses due to their high prevalence and association with severe clinical episodes. We aimed to describe and compare RSV- and hMPV-associated cases of WHO-defined severe pneumonia in a paediatric population admitted to Morocco's reference hospital. Children aged 2-59 months admitted to the Hopital d'Enfants de Rabat, Morocco meeting WHO-defined severe pneumonia criteria were recruited during 14 months and thoroughly investigated to ascertain a definitive diagnosis. Viral prevalence of RSV, hMPV and other viruses causing respiratory symptoms was investigated in nasopharyngeal aspirate samples through the use of molecular methods. Of the 683 children recruited and included in the final analysis, 61/683 (8.9%) and 124/683 (18.2%) were infected with hMPV and RSV, respectively. Besides a borderline significant tendency for higher age in hMPV cases, patients infected with either of the viruses behaved similarly in terms of demographics, patient history, past morbidity and comorbidity, vaccination history, socioeconomic background and family environment. Clinical presentation on arrival was also similar for both viruses, but hMPV cases were associated with more severity than RSV cases, had a higher risk of intensive care need, and received antibiotic treatment more frequently. RSV and hMPV are common and potentially life-threatening causes of WHO-defined pneumonia in Moroccan children. Both viruses show indistinctive clinical symptomatology, but in Moroccan children, hMPV was associated with a more severe evolution.
Filiaciones:
Jroundi I:
ISGlobal,Barcelona Centre for International Health Research (CRESIB),Hospital Clínic - Universitat de Barcelona,Barcelona,Spain
Mahraoui C:
Hôpital d'Enfants de Rabat (HER),Centre Hospitalier Universitaire Ibn Sina,Rabat,Morocco
Benmessaoud R:
ISGlobal,Barcelona Centre for International Health Research (CRESIB),Hospital Clínic - Universitat de Barcelona,Barcelona,Spain
Moraleda C:
ISGlobal,Barcelona Centre for International Health Research (CRESIB),Hospital Clínic - Universitat de Barcelona,Barcelona,Spain
Tligui H:
Hôpital d'Enfants de Rabat (HER),Centre Hospitalier Universitaire Ibn Sina,Rabat,Morocco
Seffar M:
Hôpital d'Enfants de Rabat (HER),Centre Hospitalier Universitaire Ibn Sina,Rabat,Morocco
El Kettani SE:
Hôpital d'Enfants de Rabat (HER),Centre Hospitalier Universitaire Ibn Sina,Rabat,Morocco
Benjelloun BS:
Hôpital d'Enfants de Rabat (HER),Centre Hospitalier Universitaire Ibn Sina,Rabat,Morocco
Chaacho S:
ISGlobal,Barcelona Centre for International Health Research (CRESIB),Hospital Clínic - Universitat de Barcelona,Barcelona,Spain
Munoz-Almagro C:
University Hospital Sant Joan de Déu,Esplugues,Barcelona,Spain
Ruiz J:
ISGlobal,Barcelona Centre for International Health Research (CRESIB),Hospital Clínic - Universitat de Barcelona,Barcelona,Spain
Alonso PL:
ISGlobal,Barcelona Centre for International Health Research (CRESIB),Hospital Clínic - Universitat de Barcelona,Barcelona,Spain
Bassat Q:
ISGlobal,Barcelona Centre for International Health Research (CRESIB),Hospital Clínic - Universitat de Barcelona,Barcelona,Spain
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