Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25.
Por:
Valero R, Bayés M, Francisca Sánchez-Font M, González-Angulo O, Gonzalez R and Marfany G
Publicada:
13 sep 2001
Resumen:
The ubiquitin-dependent protein degradation pathway is essential for the proteolysis of intracellular proteins and peptides. Deubiquitinating enzymes constitute a complex protein family involved in a multitude of cellular processes. The ubiquitin-specific proteases (UBP) are a group of enzymes whose predicted function is to reverse the ubiquitinating reaction by removing ubiquitin from a large variety of substrates. We have lately reported the characterization of human USP25, a specific-ubiquitin protease gene at 21q11.2, with a specific pattern of expression in murine fetal brains and adult testis.
Filiaciones:
Valero R:
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 08028 Barcelona, Spain.
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