Antioxidant status in anorexia nervosa
Por:
Moyano D, Sierra-March C, Brandi-Tarrau N, Artuch-Iriberri R, AUREA MIRA VALLET, García-Tornel S and Vilaseca MA
Publicada:
1 ene 1999
Categoría:
Psychiatry and mental health
Resumen:
Objective: The study of the antioxidant status in female adolescents (N = 82) with anorexia nervosa, by the measurement of erythrocyte tocopherol concentration, and the determination of activities of the main antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. Method: Tocopherol was measured by high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection, and antioxidant enzyme activities by spectrometric methods using a Cobas Fara automated centrifugal analyzer. Results: Tocopherol was significantly decreased in the anorexic patients compared to reference values (p < .02). In 21% of patients, tocopherol levels were below the reference interval. Superoxide dismutase activity was significantly decreased (p < .0001) while catalase activity was increased (p < .0001). The activity of the glutathione system enzymes did not show significant differences between patients and controls. Discussion: The deficient concentration of erythrocyte tocopherol together with the altered antioxidant enzyme activities suggest a certain degree of oxidative damage in anorexia nervosa owing to both factors deficient micronutrient intake and oxidative stress. (C) 1999 by John Wiley & Sons, Inc.
Filiaciones:
Moyano D:
Department of Biochemistry, Hospital Universitari Sant Joan de Déu, Barcelona, Spain
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