Antioxidant status in anorexia nervosa
Por:
Moyano D, Sierra-March C, Brandi-Tarrau N, Artuch-Iriberri R, AUREA MIRA VALLET, García-Tornel S and Vilaseca MA
Publicada:
1 ene 1999
Categoría:
Psychiatry and mental health
Resumen:
Objective: The study of the antioxidant status in female adolescents (N = 82) with anorexia nervosa, by the measurement of erythrocyte tocopherol concentration, and the determination of activities of the main antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. Method: Tocopherol was measured by high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection, and antioxidant enzyme activities by spectrometric methods using a Cobas Fara automated centrifugal analyzer. Results: Tocopherol was significantly decreased in the anorexic patients compared to reference values (p < .02). In 21% of patients, tocopherol levels were below the reference interval. Superoxide dismutase activity was significantly decreased (p < .0001) while catalase activity was increased (p < .0001). The activity of the glutathione system enzymes did not show significant differences between patients and controls. Discussion: The deficient concentration of erythrocyte tocopherol together with the altered antioxidant enzyme activities suggest a certain degree of oxidative damage in anorexia nervosa owing to both factors deficient micronutrient intake and oxidative stress. (C) 1999 by John Wiley & Sons, Inc.
Filiaciones:
Moyano D:
Department of Biochemistry, Hospital Universitari Sant Joan de Déu, Barcelona, Spain
Hosp Univ Sant Joan Deu, Dept Biochem, Barcelona 08950, Spain
Hosp Univ Sant Joan Deu, Dept Invest, Barcelona 08950, Spain
Hosp San Juan Dios, Dept Pediat, Unitat Integrada Hosp Clin, Barcelona, Spain
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