Assessment of Medication Adherence in a Cohort of Patients with Bipolar Disorder
Por:
González-Pinto A, Reed C, Novick D, Bertsch J and Haro JM
Publicada:
1 nov 2010
Resumen:
Introduction This study aimed to identify factors associated with
medication adherence in bipolar disorder (BPD) patients
Methods EMBLEM is a 2-year, prospective observational study on the
outcomes of BPD patients initiating or changing treatment for a
manic/mixed episode Data were collected at baseline during the first 12
weeks of treatment (acute phase) and up to 24 months of follow-up
(maintenance phase) Adherence was assessed by investigators at every
visit Repeated measures logistic regression analyses identified
variables associated with adherence
Results Of 1 831 patients included in the analysis, 76 6% were adherent
and 23 4% were non-adherent with their BPD medication during the
maintenance phase Patients were more likely to be adherent if they had
insight into their illness at week 12 Patients were less likely to be
adherent if they had cannabis abuse/dependence during the acute phase,
work impairment or higher CGI hallucinations/delusions at baseline
Discussion Psychotic symptoms poor insight, cannabis abuse/dependence
and work impairment are negatively related to medication adherence
during maintenance therapy of bipolar disorder Patients with these
characteristics may need a different therapeutic approach
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