Endocrine sequelae in childhood cancer survivors.
Por:
Casano-Sancho P
Publicada:
1 nov 2017
Ahead of Print:
4 oct 2017
Resumen:
Thanks to the advances in cancer treatment, the five-year survival rate after childhood cancer has increased up to 80%. Therefore 1/500 young adults will be a survivor. Endocrine sequelae are most common, affecting 40-60% of survivors. The most frequent sequelae include growth failure and gonadal and thyroid diseases. Sequelae occur more frequently in survivors from central nervous system tumors, leukemia, and lymphoma. Their development will depend on the type of cancer, its location, age at diagnosis, and treatment administered. Treatments associated to more endocrine sequels are cranial radiotherapy and hematopoietic cell transplantation. Because of the high prevalence of endocrine sequelae, international guidelines recommend endocrinologists to prospectively evaluate the survivors. As some of these endocrine changes will not develop until adult life, transition programs should be implemented, and active investigation should be made to decrease the endocrine consequences of cancer treatment.
Filiaciones:
Casano-Sancho P:
Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Universidad de Barcelona, Esplugues, Barcelona, España
Unidad de Seguimiento del Superviviente de Cáncer Infantil, Servicio de Endocrinología Pediátrica, Hospital Sant Joan de Déu, Esplugues, Barcelona, España
CIBERDEM, Instituto de Salud Carlos III, Madrid, España
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