Low-dose vitamin D supplementation and incident frailty in older people: An eight year longitudinal study.
Por:
Bolzetta F, Stubbs B, Noale M, Vaona A, Demurtas J, Celotto S, Cester A, Maggi S, Koyanagi A, Cereda E and Veronese N
Publicada:
1 ene 2018
Ahead of Print:
11 nov 2017
Resumen:
Hypovitaminosis D is associated with frailty, but if vitamin D supplementation may prevent the onset of frailty is poorly known. Therefore, we aimed to investigate whether vitamin D supplementation is associated with a lower risk of frailty. In this longitudinal study, 4,421 individuals at high risk or having knee osteoarthritis free from frailty at baseline (mean age: 61.3, females=58.0%) were followed for 8 years. Details regarding vitamin D supplementation were captured by asking whether the participant took vitamin D during the previous year, at least once per month. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence of at least two of the following criteria: (i) weight loss=5% between baseline and any subsequent follow-up visit; (ii) inability to do five chair stands; (iii) low energy level according to the SOF definition. Multivariable Cox's regression analyses, calculating hazard ratios (HRs) with 95% confidence intervals (CIs), were undertaken. At baseline 69.7% took vitamin D supplements in the previous year, with a mean dose of 384±157 IU per day. During the 8-year follow-up, no difference in the incidence of frailty was evident by vitamin D supplementation status at baseline, even after adjusting for 13 baseline confounders (HR=0.95; 95% CI: 0.72-1.25). Similar results were obtained using the propensity score (HR=0.95; 95% CI: 0.71-1.25) or age- and sex-matched controls (HR=1.00; 95% CI: 0.75-1.33). In conclusion, low-dose vitamin D supplementation was not associated with any decreased risk of frailty during eight years of follow-up in a large cohort of North American people. Future large-scale trials with high doses of oral vitamin D and longer follow-up are needed to confirm/refute our findings.
Filiaciones:
Bolzetta F:
Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 "Serenissima", Dolo-Mirano District, Italy
Stubbs B:
South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, United Kingdom
Faculty of Health, Social care and Education, Anglia Ruskin University, Bishop Hall Lane, Chelmsford CM1 1SQ, United Kingdom
Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, London SE5 8AF, United Kingdom
Noale M:
National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy
Vaona A:
Primary Care Department, Azienda ULSS20 Verona, Verona, Italy
Demurtas J:
Primary Care Department, Azienda USL Toscana Sud Est, Grosseto, Italy
Celotto S:
Primary Care Department, Aziendale AAS3 Alto Friuli - Collinare - Medio Friuli, Udine, Italy
Cester A:
Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 "Serenissima", Dolo-Mirano District, Italy
Maggi S:
National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Barcelona, Spain
Cereda E:
Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Veronese N:
National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy
Laboratory of Nutritional Biochemistry, Research Hospital, IRCCS "S. de Bellis", Castellana Grotte, Bari, Italy
Green Accepted
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