The prevalence of narcolepsy in Catalunya (Spain).
Por:
Tió E, Gaig C, Giner-Soriano M, Romero O, Jurado MJ, Sansa G, Pujol M, Sans-Capdevila O, Álvarez-Guerrico I, Caballol N, Jimenez M, Becerra JL, Escartin A, Monasterio C, Molins A, Bove A, Viña J, Iranzo A, Cambrodi R, Calvo G, Morros R and Santamaria J
Publicada:
1 oct 2018
Ahead of Print:
24 nov 2017
Resumen:
Previous studies have estimated an overall prevalence for narcolepsy between 15 and 70 cases per 100 000 inhabitants. We aimed to estimate the prevalence of narcolepsy in Catalunya (Catalonia), a north-east region of Spain (7 424 754 inhabitants), on 31 December 2014 by identifying all living subjects diagnosed with narcolepsy. First, we identified patients diagnosed by one of the 13 sleep, paediatric or neurological departments that perform tests regularly to diagnose narcolepsy. In a second phase, we searched for additional patients with narcolepsy in a clinical database of the primary health-care system. Clinical files were reviewed and narcolepsy diagnosis validated according to the Brighton Collaboration case definitions. Three hundred and twenty-five patients had a validated diagnosis of narcolepsy in the specialized centres (mean age: 44.6 years, range: 6-89; male: 60.3%; 85% with narcolepsy type 1), including 17.8% cases in Brighton, definition level 1, 62.5% in level 2, 15.4% in level 3 and 4.3% in level 4a. The overall prevalence for narcolepsy was 4.4; 3.7 for narcolepsy type 1 and 0.7 cases per 100 000 inhabitants for narcolepsy type 2. Fifty-six additional narcoleptic patients were identified in the primary health-care system, increasing the overall prevalence to 5.2 cases per 100 000 inhabitants. Prevalence rates for narcolepsy type 1 increased from childhood to adulthood, but in subjects aged more than 50 years there was a substantial drop in prevalence rates, suggesting the presence of a significant pool of undiagnosed cases in this population. Narcolepsy can be considered a rare neurological disorder in Catalunya.
Filiaciones:
Tió E:
Neurology Department, Althaia, Xarxa Assistencial Universitària, Manresa, Spain
Gaig C:
Multidisciplinary Sleep Unit, Neurology Department, Hospital Clínic Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Giner-Soriano M:
Institut Universitari d'Investigació en Atenció Primaria (IDIAP) Jordi Gol, Institut Català de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain
Romero O:
Multidiscilplinary Sleep Unit, Neurophisiology Department, Hospital Vall d'Hebrón, Barcelona, Spain
Jurado MJ:
Multidiscilplinary Sleep Unit, Neurophisiology Department, Hospital Vall d'Hebrón, Barcelona, Spain
Sansa G:
Multidisciplinary Sleep Unit, Neurology Department, Hospital Parc Taulí, Sabadell, Spain
Pujol M:
Multidisciplinary Sleep Unit, Neurology Department, Hospital Universitari Santa Maria Lleida, Lleida, Spain
Sans-Capdevila O:
Multidisciplinary Sleep Unit, Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain
Álvarez-Guerrico I:
Multidisciplinary Sleep Unit, Neurophisiology Department, Hospital del Mar, Barcelona, Spain
Caballol N:
Neurology Department, Hospital Moisès Broggi, Sant Joan Despí, Spain
Jimenez M:
Neurology Department, Hospital Germans Trías i Pujol, Badalona, Spain
Becerra JL:
Neurology Department, Hospital Germans Trías i Pujol, Badalona, Spain
Escartin A:
Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Monasterio C:
Multidisciplinary Sleep Unit, Respiratory Department, Hospital Universitari de Bellvitge, Catalunya, Spain
Molins A:
Neurology Department, Hospital Universitari Josep Trueta, Girona, Spain
Bove A:
Sleep Unit, Hospital de Sant Pau i Santa Tecla, Tarragona, Spain
Viña J:
Neurology Department, Hospital Joan XXIII, Tarragona, Spain
Iranzo A:
Multidisciplinary Sleep Unit, Neurology Department, Hospital Clínic Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Cambrodi R:
Multidiscilplinary Sleep Unit, Neurophisiology Department, Hospital Vall d'Hebrón, Barcelona, Spain
Calvo G:
Department of Clinical Pharmacology, Hospital Clínic Barcelona, Barcelona, Spain
Morros R:
Institut Universitari d'Investigació en Atenció Primaria (IDIAP) Jordi Gol, Institut Català de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain
Santamaria J:
Multidisciplinary Sleep Unit, Neurology Department, Hospital Clínic Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Open Access
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