Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event: Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)
Por:
Milman A, Andorin A, Gourraud JB, Postema PG, Sacher F, Mabo P, Kim SH, Juang JJ, Maeda S, Takahashi Y, Kamakura T, Aiba T, Conte G, Sarquella-Brugada G, Leshem E, Rahkovich M, Hochstadt A, Mizusawa Y, Arbelo E, Huang Z, Denjoy I, Giustetto C, Wijeyeratne YD, Napolitano C, Michowitz Y, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Tfelt-Hansen J, Priori SG, Takagi M, Veltmann C, Delise P, Corrado D, Behr ER, Gaita F, Yan GX, Brugada-Terradellas J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V and Belhassen B
Publicada:
1 may 2018
Ahead of Print:
8 ene 2018
Resumen:
BACKGROUND Detailed information on the profile of patients with Brugada syndrome (BrS) presenting their first arrhythmic event (AE) after prophylactic implantation of an implantable cardioverter-defibrillator (ICD) is limited.
OBJECTIVES The objectives of this study were (1) to compare clinical, electrocardiographic, electrophysiologic, and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (group A) with profiles of those in whom the AE was documented after prophylactic ICD implantation (group B) and (2) to characterize group B patients' profile using the class II indications for ICD implantation established by HRS/EH RA/APH RS expert consensus statement in 2013.
METHODS A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 patients with BrS who exhibited their AE (group A, n = 426; group B, n = 252).
RESULTS The first AE occurred in group B patients 6.7 years later than in group A (mean age 46.1 +/- 13.3 years vs 39.4 +/- 15.1 years; P < .001). Group B patients had a higher incidence of family history of sudden cardiac death and SCN5A mutations. Of the 252 group B patients, 189 (75%) complied with the HRS/EHRA/APHRS indications whereas the remaining 63 (25%) did not.
CONCLUSION Patients with BrS with the first AE documented after prophylactic ICD implantation exhibited their AE at a later age with a higher incidence of positive family history of sudden cardiac death and SCN5A mutations as compared with those presenting with aborted cardiac arrest. Only 75% of patients who exhibited an AE after receiving a prophylactic ICD complied with the 2013 class II indications, suggesting that efforts are still required for improving risk stratification.
Filiaciones:
Milman A:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Andorin A:
L'institut du Thorax, Service de Cardiologie, CHU de Nantes, Nantes, France
Gourraud JB:
L'institut du Thorax, Service de Cardiologie, CHU de Nantes, Nantes, France
Postema PG:
Heart Centre AMC, Department of Clinical and Experimental Cardiology, University of Amsterdam, Amsterdam, Netherlands
Sacher F:
Hôpital Cardiologique du Haut-Lévêque & Université Bordeaux, LIRYC Institute, Bordeaux, France
Mabo P:
Cardiology and Vascular Disease Division, Rennes University Health Centre, Rennes, France
Kim SH:
Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Juang JJ:
Cardiovascular Center and Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Maeda S:
Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan
Takahashi Y:
Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan
Kamakura T:
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
Aiba T:
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
Conte G:
Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium
Sarquella-Brugada G:
Pediatric Arrhythmias, Electrophysiology and Sudden Death Unit Cardiology, Department Hospital Sant Joan de Déu, Barcelona - Universitat de Barcelona, Spain
Leshem E:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Rahkovich M:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Arrhythmia Services, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Hochstadt A:
Department of Internal Medicine J, Tel-Aviv Medical Center, Tel Aviv, Israel
Mizusawa Y:
Heart Centre AMC, Department of Clinical and Experimental Cardiology, University of Amsterdam, Amsterdam, Netherlands
Arbelo E:
Cardiology Department, Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Catalonia, Spain
Huang Z:
Department of Cardiology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
Denjoy I:
Service de Cardiologie et CNMR Maladies Cardiaques Hereditaires Rares, Hopital Bichat, and Universite Paris Diderot, Sorbonne, Paris, France
Giustetto C:
Division of Cardiology, University of Torino, Department of Medical Sciences, Città della Salute e della Scienza Hospital, Torino, Italy
Wijeyeratne YD:
Cardiovascular Sciences, St. George's University of London and Cardiology Clinical Academic Group St. George's University Hospitals NHS Foundation Trust, London, UK
Napolitano C:
Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy
Michowitz Y:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Brugada R:
Cardiovascular Genetics Center, Institut d'Investigacio Biomedica Girona-IdIBGi, Spain
Casado-Arroyo R:
Department of Cardiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium
Champagne J:
Quebec Heart and Lung Institute, Quebec City, Canada
Calo L:
Division of Cardiology, Policlinico Casilino, Roma, Italy
Tfelt-Hansen J:
The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, and Department of Medicine and Surgery, University of Copenhagen, Copenhagen, Denmark
Priori SG:
Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy
Takagi M:
Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Japan
Veltmann C:
Rhythmology and Electrophysiology, Department of Cardiology, Hannover Medical School, Hannover, Germany
Delise P:
Division of Cardiology, Hospital of Peschiera del Garda, Veneto, Italy
Corrado D:
Department of Cardiac, Thoracic and Vascular Sciences University of Padova, Padova, Italy
Behr ER:
Cardiovascular Sciences, St. George's University of London and Cardiology Clinical Academic Group St. George's University Hospitals NHS Foundation Trust, London, UK
Gaita F:
Division of Cardiology, University of Torino, Department of Medical Sciences, Città della Salute e della Scienza Hospital, Torino, Italy
Yan GX:
Lankenau Medical Center, Wynnewood, Pennsylvania, USA
Brugada-Terradellas J:
Cardiology Department, Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Catalonia, Spain
Leenhardt A:
Service de Cardiologie et CNMR Maladies Cardiaques Hereditaires Rares, Hopital Bichat, and Universite Paris Diderot, Sorbonne, Paris, France
Wilde AAM:
Heart Centre AMC, Department of Clinical and Experimental Cardiology, University of Amsterdam, Amsterdam, Netherlands
Brugada P:
Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium
Kusano KF:
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
Hirao K:
Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan
Nam GB:
Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Probst V:
L'institut du Thorax, Service de Cardiologie, CHU de Nantes, Nantes, France
Belhassen B:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Green Submitted, Bronze
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