Kinetics of Procalcitonin in Pediatric Patients on Extracorporeal Membrane Oxygenation.
Por:
Bobillo-Perez S, Rodríguez-Fanjul J, Solé-Ribalta A, Moreno-Hernando J, Balaguer-Gargallo M, Esteban-Torne E, Cambra-Lasaosa FJ and Jordán-García I
Publicada:
1 ene 2018
Ahead of Print:
8 ene 2018
Resumen:
OBJECTIVES: To assess the kinetics of procalcitonin (PCT) and C-reactive
protein (CRP) in pediatric patients who required extracorporeal membrane
oxygenation (ECMO) and to analyze its relationship with morbidity and
mortality.
PATIENTS AND METHODS: Prospective observational study including
pediatric patients who required ECMO. Both PCT and CRP were sequentially
drawn before ECMO (P0) and until 72hours after ECMO.
RESULTS: A total of 40 patients were recruited. Two cohorts were
established based on the value of the P0 PCT (>10ng/mL). Comparing the
kinetics of PCT and CRP in these cohorts, the described curves were the
expected for each clinical situation. The cutoff for P0 PCT to predict
multiple organ dysfunction syndrome was 2.55ng/mL (sensibility 83%,
specificity 100%). Both PCT and CRP did not predict risk of neurologic
sequelae or mortality in any group.
CONCLUSIONS: Procalcitonin does not seem to be modified by ECMO and
could be a good biomarker of evolution.
Filiaciones:
Bobillo-Perez S:
Pediatric Intensive Care Unit Service, Hospital Sant Joan de Déu and University of Barcelona, Barcelona, Spain
Rodríguez-Fanjul J:
Neonatal Intensive Care Unit Service, Maternal, Fetal and Neonatology Center Barcelona (BCNatal), Hospital Sant Joan de Déu and University of Barcelona, Barcelona, Spain
Solé-Ribalta A:
Pediatric Intensive Care Unit Service, Hospital Sant Joan de Déu and University of Barcelona, Barcelona, Spain
Moreno-Hernando J:
Neonatal Intensive Care Unit Service, Maternal, Fetal and Neonatology Center Barcelona (BCNatal), Hospital Sant Joan de Déu and University of Barcelona, Barcelona, Spain
Balaguer-Gargallo M:
Pediatric Intensive Care Unit Service, Hospital Sant Joan de Déu and University of Barcelona, Barcelona, Spain
Esteban-Torne E:
Pediatric Intensive Care Unit Service, Hospital Sant Joan de Déu and University of Barcelona, Barcelona, Spain
Cambra-Lasaosa FJ:
Pediatric Intensive Care Unit Service, Hospital Sant Joan de Déu and University of Barcelona, Barcelona, Spain
Jordán-García I:
Pediatric Intensive Care Unit, Paediatric Infectious Diseases Research Group, Institut Recerca Hospital Sant Joan de Déu, Hospital Sant Joan de Déu, CIBERESP, Barcelona, Spain
Open Access
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