Chronic Physical Conditions, Multimorbidity, and Mild Cognitive Impairment in Low- and Middle-Income Countries.
Por:
Koyanagi A, Lara E, Stubbs B, Carvalho AF, Oh H, Stickley A, Veronese N and Vancampfort D
Publicada:
1 abr 2018
Ahead of Print:
10 feb 2018
Categoría:
Geriatrics and gerontology
Resumen:
OBJECTIVES: To assess the association between chronic physical conditions and multimorbidity and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). DESIGN: Nationally representative, cross-sectional, community-based study. SETTING: Six countries that participated in the World Health Organization Study on Global Ageing and Adult Health. PARTICIPANTS: Individuals aged 50 and older (N=32,715; mean age 62.1 ± 15.6; 51.7% female). MEASUREMENTS: The definition of MCI was based on the recommendations of the National Institute on Ageing and Alzheimer's Association. Ten chronic conditions were assessed (angina pectoris, arthritis, asthma, cataract, chronic lung disease, diabetes mellitus, edentulism, hearing problems, hypertension, stroke). Multivariable logistic regression analysis was conducted to assess the association between chronic physical conditions, multimorbidity (=2 chronic conditions), and MCI. RESULTS: The prevalence of multimorbidity was 49.8% (95% confidence interval (CI)=48.1-51.5%) and of MCI was 15.3% (95% CI=14.4-16.3%). After adjustment for potential confounders, edentulism (odds ratio (OR)=1.24), arthritis (OR=1.24), chronic lung disease (OR=1.29), cataract (OR=1.33), stroke (OR=1.94), hearing problems (OR=2.27), and multimorbidity (OR=1.40) were significantly associated with MCI. There was a gradual increase in the likelihood of MCI (1 condition: OR=1.21, 95% CI=1.03-1.42; =4 conditions: OR=2.07, 95% CI=1.70-2.52). CONCLUSION: These results highlight the need to investigate the underlying mechanisms linking chronic conditions and MCI and whether prevention or treatment of chronic conditions or multimorbidity can reduce the onset of cognitive decline and subsequent dementia, especially in LMICs.
Filiaciones:
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain
Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain
:
Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain
Department of Psychiatry, Universidad Autonoma de Madrid, Madrid, Spain
Stubbs B:
Physiotherapy Department, South London and Maudsley National Health Service Foundation Trust, Denmark Hill, London, United Kingdom
Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, United Kingdom
Carvalho AF:
Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil
Oh H:
School of Social Work, University of Southern California, Los Angeles, California
Stickley A:
Stockholm Center for Health and Social Change, Södertörn University, Huddinge, Sweden
Veronese N:
Geriatrics Unit, Department of Geriatric Care, OrthoGeriatrics and Rehabilitation, E.O. Galliera Hospital, National Relevance and High Specialization Hospital, Genova, Italy
National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy
Vancampfort D:
Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
University Psychiatric Center, Katholieke Universiteit Leuven, Leuven-Kortenberg, Belgium
Green Accepted, Green Published
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