Interaction between FKBP5 variability and recent life events in the anxiety spectrum: Evidence for the differential susceptibility model.
Por:
Pérez-Pérez B, Cristobal P, Sheinbaum T, Kwapil TR, Ballespí S, Peña E, de Castro-Catala M, Riba MD, Rosa A and Barrantes-Vidal N
Publicada:
21 feb 2018
Ahead of Print:
21 feb 2018
Resumen:
BACKGROUND: Gene-environment interaction (GxE) research has highlighted the importance of investigating the FK506 binding protein 51 (FKBP5) gene as a sensitivity gene. However, previous GxE studies with FKBP5 have not measured the full environmental spectrum or applied statistical tests to discern whether the GxE interaction fits better with the differential-susceptibility or diathesis-stress hypotheses. This study examined whether single nucleotide polymorphisms (SNPs) on FKBP5 gene moderate the association of positive and negative recent life events (LEs) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits. METHODS: A total of 86 nonclinical young adults were administered psychological measures and were genotyped for five FKBP5 SNPs (rs3800373, rs9296158, rs1360780, rs9470080 and rs4713916). RESULTS: Regression analyses indicated significant GxE interactions for social anxiety and neuroticism. The interactions predicting neuroticism fit different models for different SNPs, although the overall effect indicated by the haplotype was consistent with the differential-susceptibility hypothesis: the risk-haplotype group presented higher neuroticism in the presence of more negative LEs and lower neuroticism in the presence of more positive LEs. The GxE interactions for social anxiety were consistent with the diathesis-stress model. The lack of significance in the for-better side for social anxiety might be related to the fact that it mapped onto low extraversion, which is associated with a lower permeability to positive experiences. DISCUSSION: Findings underscore the importance of testing the differential-susceptibility model in relation to FKBP5 to adequately characterize its role in healthy and pathological developmental processes.
Filiaciones:
Pérez-Pérez B:
Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Cristobal P:
Research, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Barcelona, Spain
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Sheinbaum T:
Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Kwapil TR:
Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America
Ballespí S:
Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Peña E:
Secció de Zoologia i Antropologia Biològica, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Universitat de Barcelona (UB), Barcelona, Spain
Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
de Castro-Catala M:
Secció de Zoologia i Antropologia Biològica, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Universitat de Barcelona (UB), Barcelona, Spain
Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
Riba MD:
Departament de Psicobiologia i Metodologia de Ciències de la Salut, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Rosa A:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Secció de Zoologia i Antropologia Biològica, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Universitat de Barcelona (UB), Barcelona, Spain
Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
Barrantes-Vidal N:
Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Sant Pere Claver-Fundació Sanitària, Barcelona, Spain
|