Prevalence, antimicrobial resistance and serotype distribution of group B streptococcus isolated among pregnant women and newborns in Rabat, Morocco
Por:
Moraleda C, Benmessaoud R, Esteban J, López Y, Alami H, Barkat A, Houssain T, Kabiri M, Bezad R, Chaacho S, Madrid L, Vila J, Munoz-Almagro C, Bosch J, Soto SM and Bassat Q
Publicada:
1 may 2018
Ahead of Print:
15 mar 2018
Resumen:
Purpose. Group B streptococcus (GBS) is an important cause of neonatal sepsis worldwide. Data on the prevalence of maternal GBS colonization, risk factors for carriage, antibiotic susceptibility and circulating serotypes are necessary to tailor adequate locally relevant public health policies.
Methodology. A prospective study including pregnant women and their newborns was conducted between March and July 2013 in Morocco. We collected clinical data and vagino-rectal and urine samples from the recruited pregnant women, together with the clinical characteristics of, and body surface samples from, their newborns. Additionally, the first three newborns admitted every day with suspected invasive infection were recruited for a thorough screening for neonatal sepsis. Serotypes were characterized by molecular testing.
Results. A total of 350 pregnant women and 139 of their newborns were recruited. The prevalence of pregnant women colonized by GBS was 24 %. In 5/160 additional sick newborns recruited with suspected sepsis, the blood cultures were positive for GBS. Gestational hypertension and vaginal pruritus were significantly associated with a vagino-rectal GBS colonization in univariate analyses. All of the strains were susceptible to penicillin, while 7 % were resistant to clindamycin and 12 % were resistant to erythromycin. The most common GBS serotypes detected included V, II and III.
Conclusion. In Morocco, maternal GBS colonization is high. Penicillin can continue to be the cornerstone of intrapartum antibiotic prophylaxis. A pentavalent GBS vaccine (Ia, Ib, II, III and V) would have been effective against the majority of the colonizing cases in this setting, but a trivalent one (la, lb and III) would only prevent 28 % of the cases.
Filiaciones:
Moraleda C:
2?Sección de Enfermedades Infecciosas de Pediatría, Hospital Universitario 12 de Octubre, Universidad Complutense, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
Benmessaoud R:
3?Laboratoire National de Reference, BD Mohamed Taieb Naciri, Hay el Hassani, Casablanca, Morocco
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
Esteban J:
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
López Y:
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
Alami H:
4?Équipe de Recherche de Périnatologie, Université Mohammed V, Rabat, Morocco
Barkat A:
5?Équipe de Recherche en Santé et Nutrition du Couple Mère Enfant, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Morocco
Houssain T:
6?Laboratoire de Recherche. Centre Hôpitalier Universitaire (CHU) Ibn Sina, Rabat, Morocco
Kabiri M:
5?Équipe de Recherche en Santé et Nutrition du Couple Mère Enfant, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Morocco
Bezad R:
4?Équipe de Recherche de Périnatologie, Université Mohammed V, Rabat, Morocco
Chaacho S:
7?Centre Hôpitalier Universitaire (CHU) Ibn Sina, Rabat, Morocco
Madrid L:
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
:
8?School of Medicine, University of Barcelona, Barcelona, Spain
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
Munoz-Almagro C:
11?Ciber de Epidemiología y Salud Pública, CIBERESP, Madrid, Spain
10?School of Medicine, Universitat Internacional de Catalunya, Barcelona, Spain
9?Department of Molecular Microbiology, University Hospital Sant Joan de Deu, Barcelona, Spain
Bosch J:
8?School of Medicine, University of Barcelona, Barcelona, Spain
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
Soto SM:
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
Bassat Q:
12?ICREA, Pg Lluís Companys 23, 08010 Barcelona, Spain
1?ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
13?Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique
14?Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu (University of Barcelona), Barcelona, Spain
Green Accepted, Bronze
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