Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome
Por:
Michowitz Y, Milman A, Sarquella-Brugada G, Andorin A, Champagne J, Postema PG, Casado-Arroyo R, Leshem E, Juang JJ, Giustetto C, Tfelt-Hansen J, Wijeyeratne YD, Veltmann C, Corrado D, Kim SH, Delise P, Maeda S, Gourraud JB, Sacher F, Mabo P, Takahashi Y, Kamakura T, Aiba T, Conte G, Hochstadt A, Mizusawa Y, Rahkovich M, Arbelo E, Huang Z, Denjoy I, Napolitano C, Brugada R, Calo L, Priori SG, Takagi M, Behr ER, Gaita F, Yan GX, Brugada-Terradellas J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V and Belhassen B
Publicada:
1 sep 2018
Ahead of Print:
9 abr 2018
Resumen:
BACKGROUND The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series.
OBJECTIVE The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS.
METHODS The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n 252).
RESULTS In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 +/- 24 years (range 0.3-76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0-5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years.
CONCLUSION The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.
Filiaciones:
Michowitz Y:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Milman A:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Sarquella-Brugada G:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Pediatric Arrhythmias, Electrophysiology and Sudden Death Unit, Cardiology Department, Hospital Sant Joan de Déu, Barcelona - Universitat de Barcelona, Spain
Andorin A:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
L'institut du Thorax, Service de Cardiologie, CHU de Nantes, Nantes, France
Champagne J:
Quebec Heart and Lung Institute, Quebec City, Canada
Postema PG:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Heart Centre AMC, Department of Clinical and Experimental Cardiology, AMC, University of Amsterdam, Amsterdam Netherlands
Casado-Arroyo R:
Department of Cardiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium
Leshem E:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Juang JJ:
Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Giustetto C:
Division of Cardiology, University of Torino, Department of Medical Sciences, Città della Salute e della Scienza Hospital, Torino, Italy
Tfelt-Hansen J:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark
Wijeyeratne YD:
Cardiovascular Sciences, St. George's University of London and Cardiology Clinical Academic Group St. George's University Hospitals NHS Foundation Trust, London, UK
Veltmann C:
Rhythmology and Electrophysiology, Department of Cardiology, Hannover Medical School, Hannover, Germany
Corrado D:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Department of Cardiac, Thoracic and Vascular Sciences University of Padova, Padova, Italy
Kim SH:
Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Delise P:
Division of Cardiology, Hospital of Peschiera del Garda, Veneto, Italy
Maeda S:
Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan
Gourraud JB:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
L'institut du Thorax, Service de Cardiologie, CHU de Nantes, Nantes, France
Sacher F:
Hôpital Cardiologique du Haut-Lévêque Université Bordeaux, LIRYC Institute.), Bordeaux, France
Mabo P:
Cardiology and Vascular Disease Division, Rennes University Health Centre, Rennes, France
Takahashi Y:
Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan
Kamakura T:
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
Aiba T:
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
Conte G:
Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium
Hochstadt A:
Department of Internal Medicine J, Tel-Aviv Medical Center, Tel Aviv, Israel
Mizusawa Y:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Heart Centre AMC, Department of Clinical and Experimental Cardiology, AMC, University of Amsterdam, Amsterdam Netherlands
Rahkovich M:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Arrhythmia Services, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Arbelo E:
Cardiology Department, Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Catalonia, Spain
Huang Z:
Department of Cardiology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
Denjoy I:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Service de Cardiologie et CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat, Paris, and Université Paris Diderot, Sorbonne, Paris, France
Napolitano C:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy
Brugada R:
Cardiovascular Genetics Center, University of Girona-IDIBGI, Girona, Spain
Medical Science Department, School of Medicine, University of Girona, Girona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain
Calo L:
Division of Cardiology, Policlinico Casilino, Roma, Italy
Priori SG:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy
Takagi M:
Division of Cardiac Arrhythmia, Kansai Medical University Medical Center, Moriguchi, Japan
Behr ER:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Cardiovascular Sciences, St. George's University of London and Cardiology Clinical Academic Group St. George's University Hospitals NHS Foundation Trust, London, UK
Gaita F:
Division of Cardiology, University of Torino, Department of Medical Sciences, Città della Salute e della Scienza Hospital, Torino, Italy
Yan GX:
Lankenau Medical Center, Wynnewood, Pennsylvania, USA
Brugada-Terradellas J:
Cardiology Department, Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Catalonia, Spain
Leenhardt A:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Service de Cardiologie et CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat, Paris, and Université Paris Diderot, Sorbonne, Paris, France
Wilde AAM:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Heart Centre AMC, Department of Clinical and Experimental Cardiology, AMC, University of Amsterdam, Amsterdam Netherlands
Brugada P:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium
Kusano KF:
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
Hirao K:
Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan
Nam GB:
Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Probst V:
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-HEART)
L'institut du Thorax, Service de Cardiologie, CHU de Nantes, Nantes, France
Belhassen B:
Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Green Submitted, Bronze
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