Multiplex real-time PCR for prompt diagnosis of an outbreak of human parainfluenza 3 virus in children with acute leukemia
Por:
Berrueco R, Antón A, Rives-Solà S, Català-Temprano A, Toll T, Ruiz-Llobet A, Camós-Guijosa M, Torrebadell-Burriel M, Estella J and Munoz-Almagro C
Publicada:
1 dic 2013
Ahead of Print:
3 jul 2013
Resumen:
Human parainfluenza virus type 3 (HPIV-3) causes significant morbimortality in immunocompromised patients. Outbreaks of severe pneumonitis have been previously described in this setting.
Retrospective observational study in children diagnosed with acute leukemia and a documented HPIV-3 infection in the context of a nosocomial outbreak occurred in a single center.
During summer 2012, an HPIV-3 infection was detected in six hospitalized children with acute leukemia. All the patients had respiratory symptoms and one of them suffered from parotitis.
Early diagnoses using multiplex real-time polymerase chain reaction (PCR) let us control this outbreak. A phylogenetic analysis confirmed person-to-person transmission of a single HPIV-3 variant.
Green Submitted, Bronze
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