Dynamic Trajectories of Left Ventricular Ejection Fraction in Heart Failure.
Por:
Lupón J, Gavidia G, Ferrer Vidal-Barraquer E, de Antonio M, Perera A, López-Ayerbe J, Domingo M, Núñez J, Zamora E, Moliner P, Díaz-Ruata P, Santesmases J and Bayés-Genís A
Publicada:
7 ago 2018
Categoría:
Cardiology and cardiovascular medicine
Resumen:
BACKGROUND: Long-term trajectories of left ventricular ejection fraction (LVEF) in heart failure (HF) are incompletely characterized. OBJECTIVES: This study sought to examine LVEF trajectories in HF with reduced LVEF (<40%) and mid-range LVEF (40% to 49%) and the prognostic impact of LVEF dynamic changes over 15-year follow-up. METHODS: In this prospective, consecutive, observational registry of real-life HF outpatients, the authors performed 2-dimensional echocardiography at baseline and on a structured schedule after 1 year and then every 2 years up to 15 years. RESULTS: The mean number of LVEF measurements in the 1,160 included patients was 3.6 ± 1.7. As a whole, Loess curves of long-term LVEF trajectories showed an inverted U shape with a marked rise in LVEF during the first year, maintained up to a decade, and a slow LVEF decline thereafter (p for trajectory <0.001). This pattern was more pronounced in HF of nonischemic origin and in women. Patients with new-onset HF (=12 months) had a higher early increase in LVEF, whereas patients with ischemic HF showed a lower LVEF increase at 1 year; both groups had a relative plateau thereafter. Patients with HF with mid-range LVEF had less of an increase (3 ± 9%) than those with HF with reduced LVEF (9 ± 12%) during the first year (p < 0.001), but the groups overlapped after 15 years. Patients who died had lower final LVEF and worse LVEF dynamics in the immediately preceding period than survivors. CONCLUSIONS: LVEF trajectories vary in HF depending on a number of disease modifiers, but an inverted U-shaped pattern with lower LVEF at both ends of the distribution emerged. A declining LVEF in the preceding period was associated with higher mortality.
Filiaciones:
Lupón J:
Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigatión Biomédica en Red (CIBER) Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain
Gavidia G:
Department of e-Health, Eurecat, Technological Center of Catalonia, Barcelona, Spain
Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya, Barcelona, Spain
Ferrer Vidal-Barraquer E:
Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
de Antonio M:
Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Perera A:
Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya, Barcelona, Spain
Networking Biomedical Research Centre in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid, Spain
Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
López-Ayerbe J:
Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Domingo M:
Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Núñez J:
Centro de Investigatión Biomédica en Red (CIBER) Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain
Cardiology Department, Hospital Clínico Universitario, INCLIVA, València, Spain
Department of Medicine, Universitat de València, Valencia, Spain
Zamora E:
Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigatión Biomédica en Red (CIBER) Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain
Moliner P:
Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Díaz-Ruata P:
Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya, Barcelona, Spain
Networking Biomedical Research Centre in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid, Spain
Santesmases J:
Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Bayés-Genís A:
Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigatión Biomédica en Red (CIBER) Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain
Open Access
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