Intrauterine growth restriction and later cardiovascular function


Por: Crispi F, Crovetto F and Gratacós E

Publicada: 1 nov 2018 Ahead of Print: 8 sep 2018
Resumen:
Intrauterine growth restriction is one of the most common obstetric conditions, affecting 7-10% of fetuses. Affected fetuses are actually exposed in utero to an adverse environment during the highly critical time of development and may face life-long health consequences such as increased cardiovascular risk in adulthood. Already in utero, fetuses affected by growth restriction show remodeled hearts with signs of systolic and diastolic dysfunction. Cardiovascular remodeling persist into postnatal life, from the neonatal period to adolescence, suggesting a primary fetal cardiac programming that might explain the increased cardiovascular risk later in life. In this review we summarize the current evidence on fetal cardiovascular programming in fetuses affected by growth restriction, its consequences later and possible strategies from which they could benefit to reduce their cardiovascular risk.

Filiaciones:
Crispi F:
 Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), ICGON, IDIBAPS, University of Barcelona, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain

Crovetto F:
 Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), ICGON, IDIBAPS, University of Barcelona, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain

Gratacós E:
 Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), ICGON, IDIBAPS, University of Barcelona, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain

Univ Barcelona, Hosp Clin, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal Med Res Ctr,Ctr Biomed Res Rare Dis CIBER E, Barcelona, Spain.
Univ Barcelona, Hosp St Joan de Deu, Ctr Biomed Res Rare Dis CIBER ER, ICGON,IDIBAPS, Barcelona, Spain.
ISSN: 03783782





EARLY HUMAN DEVELOPMENT
Editorial
ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE 00000, IRELAND, Países Bajos
Tipo de documento: Article
Volumen: 126 Número:
Páginas: 23-27
WOS Id: 000449445800005
ID de PubMed: 30206007
imagen Green Accepted

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