A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation
Por:
Bassols J, Megia A, Soriano-Rodríguez P, Díaz-Silva M, Prats-Puig A, Gifre M, Simón-Muela I, Torrent S, Borrell AC, Riera-Socasau JC, Vendrell J, de Zegher F, Ibañez-Toda L and López-Bermejo A
Publicada:
1 sep 2013
Resumen:
Objective: To assess whether the common rs8111699 (C528G) variant in STK11 is related to metabolic risk markers in pregnant women and to gestational diabetes mellitus (GDM).
Design: Cross-sectional study.
Setting: Hospital.
Patient(s): A total of 561 pregnant women: 318 without and 243 with GDM (National Diabetes Data Group criteria).
Intervention(s): None.
Main Outcome Measures(s): rs8111699 variant in STK11 (Taqman technology). Fasting glucose, insulin (homeostatic model assessment of insulin resistance and beta-cell function [HOMA-IR and -beta]) and C-peptide assessed at 24-28 weeks' gestation.
Result(s): In non-GDM women, the G allele in rs8111699 was associated with lower HOMA-IR (CC: 1.3 +/- 0.1 mIU/L; GG: 0.9 +/- 0.1 mIU/L) and HOMA-beta (CC: 165 +/- 20 mIU/L; GG: 118 +/- 10 mIU/L). In GDM women, the G allele was related to lower body mass index (BMI; CC: 27.9 +/- 1.0 kg/m(2); GG: 24.5 +/- 0.6 kg/m(2)) and C-peptide (CC: 2.3 +/- 0.1 ng/mL; GG: 1.6 +/- 0.1 ng/mL). The GG genotype was less frequently observed in GDM women (18% vs. 26%), particularly in heavier GDM women (BMI > median: 14% vs. 28%).
Conclusion(s): In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of GDM, particularly in heavier women. ((C) 2013 by American Society for Reproductive Medicine.)
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