Psychotic experiences and subjective cognitive complaints among 224 842 people in 48 low- and middle-income countries.
Por:
Koyanagi A, Stubbs B, Lara E, Veronese N, Vancampfort D, Smith L, Haro JM, Hans Oh and DeVylder JE
Publicada:
26 dic 2018
Ahead of Print:
26 dic 2018
Resumen:
AIMS: Cognitive deficits are an important factor in the pathogenesis of psychosis. Subjective cognitive complaints (SCCs) are often considered to be a precursor of objective cognitive deficits, but there are no studies specifically on SCC and psychotic experiences (PE). Thus, we assessed the association between SCC and PE using data from 48 low- and middle-income countries. METHODS: Community-based cross-sectional data of the World Health Survey were analysed. Two questions on subjective memory and learning complaints in the past 30 days were used to create a SCC scale ranging from 0 to 10 with higher scores representing more severe SCC. The Composite International Diagnostic Interview was used to identify past 12-month PE. Multivariable logistic regression and mediation analyses were performed. RESULTS: The final sample consisted of 224 842 adults aged ?18 years [mean (SD) age 38.3 (16.0) years; 49.3% males]. After adjustment for sociodemographic factors, a one-unit increase in the SCC scale was associated with a 1.17 (95% CI 1.16-1.18) times higher odds for PE in the overall sample, with this association being more pronounced in younger individuals: age 18-44 years OR = 1.19 (95% CI 1.17-1.20); 45-64 years OR = 1.15 (95% CI 1.12-1.17); ?65 years OR = 1.14 (95% CI 1.09-1.19). Collectively, other mental health conditions (perceived stress, depression, anxiety, sleep problems) explained 43.4% of this association, and chronic physical conditions partially explained the association but to a lesser extent (11.8%). CONCLUSIONS: SCC were associated with PE. Future longitudinal studies are needed to understand temporal associations and causal inferences, while the utility of SCC as a risk marker for psychosis especially for young adults should be scrutinised.
Filiaciones:
Koyanagi A:
Research and Development Unit,Parc Sanitari Sant Joan de Déu,Universitat de Barcelona,Fundació Sant Joan de Déu,Barcelona,Spain
Stubbs B:
Physiotherapy Department,South London and Maudsley NHS Foundation Trust,Denmark Hill,London,UK
:
Instituto de Salud Carlos III,Centro de Investigación Biomédica en Red de Salud Mental,CIBERSAM,Madrid,Spain
Veronese N:
National Research Council,Neuroscience Institute,Aging Branch,Padova,Italy
Vancampfort D:
Department of Rehabilitation Sciences,KU Leuven,Leuven,Belgium
Smith L:
The Cambridge Centre for Sport and Exercise Sciences,Department of Life Sciences,Anglia Ruskin University,Cambridge,UK
Haro JM:
Research and Development Unit,Parc Sanitari Sant Joan de Déu,Universitat de Barcelona,Fundació Sant Joan de Déu,Barcelona,Spain
Hans Oh:
University of Southern California,Suzanne Dworak-Peck School of Social Work,Los Angeles, CA,USA
DeVylder JE:
Graduate School of Social Service,Fordham University,New York, NY,USA
Green Published, Green Accepted, hybrid
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