Nerve Growth Factor Levels in Term Human Infants: Relationship to Prenatal Growth and Early Postnatal Feeding
Por:
Sánchez-Infantes D, Cereijo R, Sebastiani G, Pérez-Cruz M, Villarroya-Gombau F and Ibañez-Toda L
Publicada:
1 ene 2018
Ahead of Print:
23 dic 2018
Resumen:
Background. Nerve growth factor (NGF) plays a key role in neuroprotection and developmental maturity. We assessed longitudinally the circulating concentrations of NGF in term healthy human newborns and infants as well as their association with prenatal growth and early postnatal feeding patterns. Methods. Circulating NGF and anthropometric measures (weight, length, body mass index, and ponderal index) were assessed longitudinallyat birth and at age 4 monthsin 86 term infants born appropriate (AGA), small (SGA), or large for gestational age (LGA). Results. Cord blood NGF levels in SGA newborns were higher than those in AGA newborns (1.41 +/- 0.2pg/mL vs. 0.66 +/- 0.1pg/mL; p=0.02) and not different from those in LGA neonates (0.79 +/- 0.2pg/mL). At age 4 months, SGA-breastfed infants showed the highest NGF concentrations (p=0.02 and p=0.01 vs. AGA and SGA-formula-fed infants, respectively), while LGA infants depicted a marginal increase. NGF levels in cord blood correlated negatively with the ponderal index at birth (r=-0.36; p=0.0008). Conclusions. Circulating NGF is related to both prenatal growth and early postnatal nutrition. The maintenance of increased NGF concentrations in SGA-breastfed infants at age 4 months might be a potential mechanism to counterbalance potential risks for developing cognitive and psychomotor disadvantages.
Filiaciones:
Sánchez-Infantes D:
Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain
Cereijo R:
Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), ISCIII, Madrid, Spain
Sebastiani G:
Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid, Spain
Pérez-Cruz M:
Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain
Villarroya-Gombau F:
Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain
Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), ISCIII, Madrid, Spain
Ibañez-Toda L:
Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid, Spain
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