Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
Por:
Smith L, Luchini C, Demurtas J, Soysal P, Stubbs B, Hamer M, Nottegar A, Lawlor RT, Lopez-Sanchez GF, Firth J, Koyanagi A, Roberts J, Willeit P, Waldhoer T, Loosemore M, Abbs AD, Johnstone J, Yang L and Veronese N
Publicada:
1 may 2019
Ahead of Print:
15 feb 2019
Resumen:
The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. To evaluate the credibility of the identified evidence, we assessed also heterogeneity, evidence for small-study effect and evidence for excess significance bias. Twenty-one relevant meta-analyses were identified reporting on 50 different outcomes. The level of evidence was high only for the association of short telomeres with higher risk of gastric cancer in the general population (relative risk, RR = 1.95, 95%CI: 1.68-2.26), and moderate for the association of shorter telomeres with diabetes or with Alzheimer's disease, even if limited to meta-analyses of case-control studies. There was weak evidence for twenty outcomes and not significant association for 27 health outcomes. The present umbrella review demonstrates that shorter telomere length may have an important role in incidence gastric cancer and, probably, diabetes and Alzheimer's disease. At the same time, conversely to general assumptions, it does not find strong evidence supporting the notion that shorter telomere length plays an important role in many health outcomes that have been studied thus far.
Filiaciones:
Smith L:
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK
Luchini C:
Department of Diagnostics and Public Health, University of Verona, Italy
Demurtas J:
Primary Care Department Azienda USL Toscana Sud Est, Grosseto, Italy
Soysal P:
Kayseri Education and Research Hospital, Geriatric Center, Kayseri, Turkey
Stubbs B:
Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, London, UK
Hamer M:
School Sport Exercise Health Sciences, Loughborough University, Loughborough. UK
Nottegar A:
Department of Surgery, Section of Pathology, San Bortolo Hospital, Vicenza, Italy
Lawlor RT:
ARC-Net Research Center, University of Verona, Verona, Italy
Lopez-Sanchez GF:
Faculty of Sports Sciences, University of Murcia, Spain
Firth J:
NICM Health Research Institute, University of Western Sydney, Sydney, Australia
Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
Koyanagi A:
Parc Sanitari Sant Joan de Déu/CIBERSAM, Universitat de Barcelona, Fundació Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
Roberts J:
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK
Willeit P:
Department of Neurology, Medical University of Innsbruck, Austria
Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
Waldhoer T:
Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria
Loosemore M:
University College London, Institute of Sport, Exercise and Health, UK
Abbs AD:
Pennine Acute Hospitals, NHS Trust, UK
Johnstone J:
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK
Yang L:
Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria
Veronese N:
National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy
Ambulatory of Nutrition, IRCCS S. de Bellis National Institute of Gastroenterology-Research Hospital Castellana Grotte Bari Italy, Italy
Green Submitted, Green Accepted
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