High BDNF serum levels are associated to good cognitive functioning in bipolar disorder.
Por:
Ester Mora, Portella MJ, Piñol-Ripoll G, López R, Cuadras-Palleja D, Forcada I, Teres M, Vieta E and Mur M
Publicada:
1 ago 2019
Ahead of Print:
23 feb 2019
Categoría:
Psychiatry and mental health
Resumen:
BACKGROUND: Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity. To date, there is a lack of studies linking the cognitive impairment observed in BD with these neurobiological mechanisms. This study aimed to investigate the role of these neurobiological factors in clinical and cognitive outcomes in a sample of bipolar individuals. METHODS: We measured serum BDNF, cytokines and oxidative stress markers in a sample of 133 individuals: 52 euthymic bipolar patients, 32 manic patients and 49 healthy controls. They were all assessed with a comprehensive cognitive battery. Sociodemographic and clinical data were collected. Multiple linear regression models were built to study associations of neurotrophins and inflammatory and oxidative measures with cognitive functioning. RESULTS: BDNF levels were decreased in euthymic (p = 0.039) and manic (p < 0.001) individuals. Conversely, inflammatory (interleukin 6 (IL-6)) (p = 0.019) and oxidative stress (p = 0.003) measures were increased in bipolar individuals compared to controls. BDNF levels were associated with executive functioning (ß = 0.01, p = 0.02) and verbal memory (ß = 0.013, p = 0.005), together with other demographic variables. In particular, verbal memory was also associated with obesity (ß=-0.04, p = 0.005). Neither inflammatory markers, oxidative stress markers nor other relevant clinical variables showed any association with cognitive outcome. CONCLUSIONS: Of all the peripheral neurobiological factors analysed, BDNF was the only one significantly associated with cognitive dysfunction in bipolar disorder individuals. This study emphasizes the role of BDNF not only across mood phases but also in cognitive functioning.
Filiaciones:
Ester Mora:
Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain
Child and Adolescent Mental Health Centre, Hospital Sant Joan de Déu Terres de Lleida, Catalonia, Spain
Portella MJ:
Psychiatric Service, Research Institute, Hospital de Santa Creu i Sant Pau, Autonomous University of Barcelona, CIBERSAM, Barcelona, Catalonia, Spain
Piñol-Ripoll G:
Cognitive Disorders Unit, Hospital Universitari Santa Maria, Neuroscience Clinical Group, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain
López R:
Laboratory Department, Hospital Universitari Arnau de Vilanova, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain
Cuadras-Palleja D:
Statistics Unit. Sant Joan de Déu Research Fundation, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Catalonia, Spain
Forcada I:
Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain
Teres M:
Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain
Vieta E:
Bipolar Disorder Program, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain
Mur M:
Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarré Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain
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