The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
Por:
Tyrovolas S, Panagiotakos DB, Georgousopoulou EN, Chrysohoou C, Skoumas J, Pan W, Tousoulis D and Pitsavos C
Publicada:
23 jun 2019
Ahead of Print:
23 jun 2019
Categoría:
Gastroenterology
Resumen:
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet's inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-inflammatory diet, as reflected by the Dietary Anti-Inflammation Index (D-AII), and NAFLD among cardiovascular disease (CVD)-free adults. METHODS: ATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek population (Whites; age ?18 years; 1514 men and 1528 women). D-AII was calculated using a standard procedure. The baseline study captured various sociodemographic, lifestyle and clinical characteristics as well as hepatic markers. These were used to calculate four NAFLD assessment indices: triglyceride-glucose (TyG) index, fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD Fatty Liver Score (NAFLD-FLS). Specific cutoffs were applied to capture NAFLD. RESULTS: D-AII showed a significant inverse association with NAFLD, applying the four indices with NAFLD cutoffs [odds ratio (OR) with 95% confidence interval (CI); TyG (0.95, 0.93-0.98); HSI (0.89, 0.86-0.92); FLI (0.88, 0.85-0.91); NAFLD-FLS (0.89, 0.86-0.92)], after adjusting for various confounders. Participants in the highest D-AII tertile had lower odds of having NAFLD, compared with those in the lowest D-AII tertile [(OR, 95% CI); TyG (0.33, 0.24-0.47); HSI (0.13, 0.08-0.23); FLI (0.05, 0.02-0.11); NAFLD-FLS (0.13, 0.07-0.23)]. Anti-inflammatory nutrition was related to lower odds of NAFLD among daily alcohol drinkers and individuals with metabolic syndrome. CONCLUSIONS: Anti-inflammatory diet is an important predictor of NAFLD among adults without pre-existing CVD. Adherence to a high anti-inflammatory diet seems to contribute to NAFLD prevention.
Filiaciones:
Tyrovolas S:
Parc Sanitari Sant Joan de Déu, Universitat de Barcelona. Fundació Sant Joan de Déu, Dr Antoni Pujades, Barcelona, Spain
Panagiotakos DB:
Department of Science of Dietetics and Nutrition, School of Health Science and Education, Harokopio University in Athens, El. Venizelou 70, Athens, 176 71, Greece Faculty of Health, University of Canberra, Canberra, Australia
Georgousopoulou EN:
Department of Science of Dietetics and Nutrition, School of Health Science and Education, Harokopio University, Athens, Greece
Chrysohoou C:
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
Skoumas J:
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
Pan W:
Nicholas School of the Environment, Duke University, Durham, NC, USA
Tousoulis D:
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
Pitsavos C:
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
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