Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
Por:
Castells-Sánchez A, Roig-Coll F, Lamonja-Vicente N, Altés-Magret M, Torán-Monserrat P, Via-Garcia M, García-Molina A, Tormos JM, Heras A, Alzamora MT, Forés R, Pera G, Dacosta-Aguayo R, Soriano-Raya JJ, Cáceres C, Montero-Alía P, Montero-Alía JJ, Jimenez-Gonzalez MM, Hernández-Pérez M, Perera A, Grove GA, Munuera-del Cerro JL, Domènech S, Erickson KI and Mataró-Serrat M
Publicada:
14 ago 2019
Ahead of Print:
14 ago 2019
Resumen:
Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses.
Methods: One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (COT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention.
Results: Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample.
Discussion: Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects.
Filiaciones:
Castells-Sánchez A:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain
Roig-Coll F:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Lamonja-Vicente N:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain
Altés-Magret M:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Torán-Monserrat P:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Via-Garcia M:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain
García-Molina A:
Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Barcelona, Spain
Tormos JM:
Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Barcelona, Spain
Heras A:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Alzamora MT:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Forés R:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Pera G:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Dacosta-Aguayo R:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Soriano-Raya JJ:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Cáceres C:
Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Montero-Alía P:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Montero-Alía JJ:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Jimenez-Gonzalez MM:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Hernández-Pérez M:
Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Perera A:
B2SLab, Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya, Barcelona, Spain
Grove GA:
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
Munuera-del Cerro JL:
Diagnostic Imaging Department, Fundació de Recerca, Hospital Sant Joan de Déu, Barcelona, Spain
Domènech S:
Institut de Diagnòstic per la Imatge, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Erickson KI:
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
Mataró-Serrat M:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain
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