Structural abnormality in schizophrenia versus bipolar disorder: A whole brain cortical thickness, surface area, volume and gyrification analyses
Por:
Madre M, Canales-Rodríguez EJ, Fuentes-Claramonte P, Alonso-Lana S, Salgado-Pineda P, Guerrero-Pedraza A, Moro N, Bosque C, Gomar JJ, Ortíz-Gil J, Goikolea JM, Bonnin CM, Vieta E, Sarró S, Maristany M, McKenna PJ, Salvador R and Pomarol-Clotet E
Publicada:
1 ene 2020
Ahead of Print:
13 dic 2019
Resumen:
Objectives: The profiles of cortical abnormalities in schizophrenia and bipolar disorder, and how far they resemble each other, have only been studied to a limited extent. The aim of this study was to identify and compare the changes in cortical morphology associated with these pathologies.
Methods: A total of 384 subjects, including 128 patients with schizophrenia, 128 patients with bipolar disorder and 127 sex-age-matched healthy subjects, were examined using cortical surface-based morphology. Four cortical structural measures were studied: cortical volume (CV), cortical thickness (CT), surface area (SA) and gyrification index (GI). Group comparisons for each separate cortical measure were conducted.
Results: At a threshold of P = 0.05 corrected, both patient groups showed significant widespread CV and CT reductions in similar areas compared to healthy subjects. However, the changes in schizophrenia were more pronounced. While CV decrease in bipolar disorder was exclusively explained by cortical thinning, in schizophrenia it was driven by changes in CT and partially by SA. Reduced GI was only found in schizophrenia. The direct comparison between both disorders showed significant reductions in all measures in patients with schizophrenia.
Conclusions: Cortical volume and cortical thickness deficits are shared between patients with schizophrenia and bipolar disorder, suggesting that both pathologies may be affected by similar environmental and neurodegenerative factors. However, the exclusive alteration in schizophrenia of metrics related to the geometry and curvature of the brain cortical surface (SA, GI) suggests that this group is influenced by additional neurodevelopmental and genetic factors.
Filiaciones:
Madre M:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain
Canales-Rodríguez EJ:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Fuentes-Claramonte P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Alonso-Lana S:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Salgado-Pineda P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Guerrero-Pedraza A:
Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain
Moro N:
Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain
Bosque C:
Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain
Gomar JJ:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
The Litwin-Zucker Alzheimer's Research Center, NY, USA
Ortíz-Gil J:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Hospital General de Granollers, Granollers, Catalonia, Spain
Goikolea JM:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Bipolar Disorder Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain
Bonnin CM:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Bipolar Disorder Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain
Vieta E:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Bipolar Disorder Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain
Sarró S:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Maristany M:
Diagnostic Imaging Department, Fundació de Recerca Hospital Sant Joan de Déu, Barcelona, Spain
McKenna PJ:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Salvador R:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Pomarol-Clotet E:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
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