The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia.
Por:
Feliu A, Martínez-Zalacaín I, Pérez A, Borràs X, Andrés L, Sanabria-Mazo JP, Fayed N, Stephan-Otto C, Nuñez C, Soriano-Mas C and Luciano JV
Publicada:
30 ene 2020
Ahead of Print:
30 ene 2020
Categoría:
Medicine (miscellaneous)
Resumen:
This study explored the brain structural correlates of psychological flexibility (PF) as measured with the Psychological Inflexibility in Pain Scale (PIPS) in patients with fibromyalgia (FM). Structural magnetic resonance imaging data from 47 FM patients were used to identify Gray Matter Volume (GMV) alterations related to PIPS scores. Brain GMV clusters related to PIPS were then correlated with clinical and cognitive variables to further explore how emerged brain clusters were intertwined with FM symptomatology. Longitudinal changes in PIPS-related brain clusters values were assessed by studying pre-post data from 30 patients (15 allocated to a mindfulness-based stress reduction (MBSR) program and 15 to treatment-as-usual). Changes in PIPS-related brain clusters were also explored in participants showing greater/lower longitudinal changes in PIPS scores. PIPS scores were positively associated with GMV in a bilateral cluster in the ventral part of the bed nucleus of the stria terminalis (BNST). Significant associations between BNST cluster with functional impairment, depressive symptomatology, perceived stress and the nonjudging mindfulness facet were observed. Participants reporting greater pre-post increases in PIPS scores showed greater increases in BNST cluster values. These findings contribute to the understanding on the neurobiological bases of PF in FM and encourage further explorations of the role of the BNST in chronic pain.
Filiaciones:
Feliu A:
Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, 08830 St. Boi de Llobregat, Spain
Faculty of Psychology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
Martínez-Zalacaín I:
Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain
Department of Clinical Sciences, School of Medicine, University of Barcelona, 08036 Barcelona, Spain
Pérez A:
Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, 08830 St. Boi de Llobregat, Spain
Faculty of Psychology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
Borràs X:
Faculty of Psychology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
Andrés L:
Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, 08830 St. Boi de Llobregat, Spain
Faculty of Psychology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
Sanabria-Mazo JP:
Faculty of Psychology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
Fayed N:
Department of Radiology, Quirónsalud Hospital, 50012 Zaragoza, Spain
Stephan-Otto C:
Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, 08830 St. Boi de Llobregat, Spain
Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain
Nuñez C:
Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, 08830 St. Boi de Llobregat, Spain
Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain
Soriano-Mas C:
Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain
Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain
Luciano JV:
Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, 08830 St. Boi de Llobregat, Spain
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