Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods.
Por:
Fernández-Yagüe M, Antoñanzas RP, Roa JJ, Biggs M, Gil-Mur FX and Pegueroles M
Publicada:
1 jun 2019
Ahead of Print:
26 feb 2019
Resumen:
Biomimetic design is a key tenet of orthopedic device technology, and in particular the development of responsive surfaces that promote ion exchange with interfacing tissues, facilitating the ionic events that occur naturally during bone repair, hold promise in orthopedic fixation strategies. Non-bioactive nanostructured titanium implants treated by shot-blasting and acid-etching (AE) induced higher bone implant contact (BIC=52% and 65%) compared to shot-blasted treated (SB) implants (BIC=46% and 47%) at weeks 4 and 8, respectively. However, bioactive charged implants produced by plasma (PL) or thermochemical (BIO) processes exhibited enhanced osteoconductivity through specific ionic surface-tissue exchange (PL, BIC= 69% and 77% and BIO, BIC= 85% and 87% at weeks 4 and 8 respectively). Furthermore, bioactive surfaces (PL and BIO) showed functional mechanical stability (resonance frequency analyses) as early as 4 weeks post implantation via increased total bone area (BAT=56% and 59%) ingrowth compared to SB (BAT=35%) and AE (BAT=35%) surfaces.
Filiaciones:
Fernández-Yagüe M:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain
CURAM, Centre for Medical Devices. National University of Ireland, Galway, Galway, Ireland
Antoñanzas RP:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain
Bioengineering Institute of Technology, School of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain
Roa JJ:
Structural Integrity, Micromechanics and Materials Reliability, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain
Biggs M:
CURAM, Centre for Medical Devices. National University of Ireland, Galway, Galway, Ireland
Gil-Mur FX:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain
Bioengineering Institute of Technology, School of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain
Pegueroles M:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), EEBE, Barcelona, Spain
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