Antimicrobial PHAs coatings for solid and porous tantalum implants.
Por:
Rodríguez-Contreras A, Guillem J, Lopez O, Manero JM and Ruperez E
Publicada:
1 oct 2019
Resumen:
Biomaterial-associated infections (BAI) are the major cause of failure of indwelling medical devices. The risk of BAI can end dramatically in the surgical removal of the affected device. Therefore, a major effort must be undertaken to guarantee the permanence of the implant. In this regard, we have developed antimicrobial coatings for tantalum (Ta) implants, using polyhydroxyalkanoates (PHAs) as matrices for carrying an active principle. The dip-coating technique was successfully used for covering solid Ta discs. An original PHA emulsion flow process was developed for the coating of porous Ta structures, specially for the inner surfaces. The complete characterization of the biopolymer coatings, their antibacterial properties, toxicity and biointegration were analyzed. Thus, non-toxic, well-biointegrated homogeneous biopolymer coatings were attained, which showed antibacterial properties. By using biodegradable PHAs, the resulting drug delivery system assured the protection of Ta against bacterial infections for a period of time.
Filiaciones:
Rodríguez-Contreras A:
Department of Materials Science and Metallurgical Engineering, Electronic Microscopy Laboratory, Polytechnic University of Catalonia. Eduard Maristany 10-14, 08930, Barcelona, Spain
Guillem J:
Department of Materials Science and Metallurgical Engineering, Biomaterials, Biomechanics and Tissue Engineering Group, Polytechnic University of Catalonia. Eduard Maristany 10-14, 08930, Barcelona, Spain
Lopez O:
Department of Materials Science and Metallurgical Engineering, Electronic Microscopy Laboratory, Polytechnic University of Catalonia. Eduard Maristany 10-14, 08930, Barcelona, Spain
Manero JM:
Department of Materials Science and Metallurgical Engineering, Electronic Microscopy Laboratory, Polytechnic University of Catalonia. Eduard Maristany 10-14, 08930, Barcelona, Spain
Department of Materials Science and Metallurgical Engineering, Biomaterials, Biomechanics and Tissue Engineering Group, Polytechnic University of Catalonia. Eduard Maristany 10-14, 08930, Barcelona, Spain
CIBER-BBN, Centro de Investigación Biomédica en Red, Madrid, Spain
Ruperez E:
Department of Materials Science and Metallurgical Engineering, Biomaterials, Biomechanics and Tissue Engineering Group, Polytechnic University of Catalonia. Eduard Maristany 10-14, 08930, Barcelona, Spain
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