A compendium answering 150 questions on COVID-19 and SARS-CoV-2.
Por:
Riggioni C, Comberiati P, Giovannini M, Agache I, Akdis M, Alves-Correia M, Antó JM, Arcolaci A, Kursat Azkur A, Azkur D, Beken B, Boccabella C, Bousquet J, Breiteneder H, Carvalho D, De Las Vecillas L, Diamant Z, Eguiluz-Gracia I, Eiwegger T, Eyerich S, Fokkens W, Gao YD, Hannachi F, Johnston SL, Jutel M, Karavelia A, Klimek L, Moya B, Nadeau K, O'Hehir R, O'Mahony L, Pfaar O, Sanak M, Schwarze J, Sokolowska M, Torres MJ, van de Veen W, van Zelm MC, Wang Y, Zhang L, Jiménez-Saiz R and Akdis CA
Publicada:
1 oct 2020
Ahead of Print:
20 jul 2020
Resumen:
In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.
Filiaciones:
:
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
Comberiati P:
Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy
Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Giovannini M:
Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy
Agache I:
Transylvania University, Faculty of Medicine, Brasov, Romania
Akdis M:
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Alves-Correia M:
Allergy Unit, CUF Porto Hospital & Institute, Oporto, Portugal. Center for Health Technology and Services Research (CINTESIS) - Faculty of Medicine of the University of Porto, Oporto, Portugal
Antó JM:
ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Arcolaci A:
Allergy Unit & Asthma Center, Borgo Roma Hospital, University of Verona and General Hospital, Verona, Italy
Kursat Azkur A:
Department of Virology, Faculty of Veterinary Medicine, University of Kirikkale, Kirikkale, Turkey
Azkur D:
Division of Pediatric Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of Kirikkale, Kirikkale, Turkey
Beken B:
Department of Pediatric Allergy and Immunology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
Boccabella C:
Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario "A Gemelli" - IRCCS, University of the Sacred Heart, Rome, Italy
Bousquet J:
Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany
MACVIA-France, Montpellier, France
Breiteneder H:
Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
Carvalho D:
Public Health Research Center, NOVA University of Lisbon, Lisboa, Portugal
De Las Vecillas L:
Department of Allergy, Marqués de Valdecilla University Hospital-IDIVAL, Santander, Spain
Diamant Z:
Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden
Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Eguiluz-Gracia I:
Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, RETICS ARADyAL, BIONAND, Malaga, Spain
Eiwegger T:
Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Toronto, Ontario, Canada
Translational Medicine Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Department of Immunology, University of Toronto, Toronto, ON, Canada
Eyerich S:
ZAUM - Center of Allergy and Environment, Technical University and Helmholtz Center Munich, Munich, Germany
Fokkens W:
Department of Otorhinolaryngology, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands
Gao YD:
Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China
Hannachi F:
Immuno-Allergology Unit, Hospital Centre of Luxembourg, Luxembourg
Johnston SL:
National Heart and Lung Institute, Imperial College London, United Kingdom
Jutel M:
University of Wroclaw, Department of Clinical Immunology, Wroclaw, Poland
ALL-MED" Medical Research Institute, Wroclaw, Poland
Karavelia A:
ENT Department, General Hospital of Chania, Greece
Klimek L:
Center for Rhinology and Allergology, Wiesbaden, Germany
Moya B:
Allergy Unit, Hospital Universitario, 12 de Octubre, Madrid, Spain
Nadeau K:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University and Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA, USA
O'Hehir R:
Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia
Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia
O'Mahony L:
Department of Medicine and School of Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland
Pfaar O:
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
Sanak M:
Department of Medicine, Jagiellonian University Medical College, Krakow, Poland
Schwarze J:
Centre for Inflammation Research, Child Life and Health, The University of Edinburgh, Edinburgh, United Kingdom
Sokolowska M:
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland
Torres MJ:
Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, RETICS ARADyAL, BIONAND, Malaga, Spain
van de Veen W:
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland
van Zelm MC:
Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia
Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia
Wang Y:
Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Zhang L:
Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Beijing, China
Jiménez-Saiz R:
Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain
McMaster Immunology Research Centre (MIRC), Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain
Akdis CA:
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Green Published, Green Accepted, Green Submitted, Bronze
|