Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies.
Por:
Soysal P, Hurst C, Demurtas J, Firth J, Howden R, Yang L, Tully MA, Koyanagi A, Ilie PC, López-Sánchez GF, Schwingshackl L, Veronese N and Smith L
Publicada:
1 may 2021
Ahead of Print:
19 jun 2020
Categoría:
Orthopedics and sports medicine
Resumen:
PURPOSE: The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes. METHODS: An umbrella review of systematic reviews with meta-analyses of observational studies was conducted. We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values, 95% prediction intervals, heterogeneity, small-study effects, and excess significance. We graded the evidence from convincing (Class I) to weak (Class IV). RESULTS: From 504 articles returned in a search of the literature, 8 systematic reviews were included in our review, with a total of 11 outcomes. Overall, nine of the 11 of the outcomes reported nominally significant summary results (p < 0.05), with 4 associations surviving the application of the more stringent p value (p < 10(-6)). No outcome presented convincing evidence. Three associations showed Class II evidence (i.e., highly suggestive): (1) higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population (n?=?34 studies; sample size?=?1,855,817; relative risk = 0.72, 95% confidence interval (95%CI): 0.67-0.78), (2) cardiovascular death risk in mixed populations (n?=?15 studies; relative risk?=?0.84, 95%CI: 0.78-0.91), and (3) incidence of disability (n?=?7 studies; relative risk?=?0.76, 95%CI: 0.66-0.87). CONCLUSION: The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality, as well as disability. To further inform intervention strategies, future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.
Filiaciones:
Soysal P:
Department of Geriatric Medicine, Bezmialem Vakif University, Istanbul 34093, Turkey
Hurst C:
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
Demurtas J:
Primary Care Department, Azienda Usl Toscana Sud Est, Grosseto 52100, Italy
Firth J:
Division of Psychology and Mental Health, University of Manchester, Manchester M13 9PL, UK
Howden R:
College of Health & Human Services, University of North Carolina at Charlotte, Long Beach, CA 90815, USA
Yang L:
Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Holy Cross Centre T5J 3E4, Canada
Tully MA:
School of Health Sciences, Institute of Mental Health Sciences, Ulster University, Newtownabbey BT15 1ED, Northern Ireland
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona 08003, Spain
ICREA, Pg. Lluís Companys 23, Barcelona 08010, Spain
Ilie PC:
The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust, King's Lynn PE30 4ET, UK
López-Sánchez GF:
Faculty of Sport Sciences, University of Murcia, Murcia 30100, Spain
Schwingshackl L:
Institute for Evidence in Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79085, Germany
Veronese N:
Neuroscience Institute, Aging Branch, National Research Council, Padua 35122, Italy
Smith L:
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK
Green Published, gold, Green Accepted
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