Tea Consumption and Risk of Cancer: An Umbrella Review and Meta-Analysis of Observational Studies.
Por:
Kim TL, Jeong GH, Yang JW, Lee KH, Kronbichler A, van der Vliet HJ, Grosso G, Galvano F, Aune D, Kim JY, Veronese N, Stubbs B, Solmi M, Koyanagi A, Hong SH, Dragioti E, Cho E, de Rezende LFM, Giovannucci EL, Shin JI and Gamerith G
Publicada:
16 nov 2020
Ahead of Print:
15 jul 2020
Resumen:
Tea is one of the most widely consumed beverages, but its association with cancer risk remains controversial and unclear. We performed an umbrella review to clarify and determine the associations between tea consumption and various types of cancer by summarizing and recalculating the existing meta-analyses. Meta-analyses of observational studies reporting associations between tea consumption and cancer risk were searched on PubMed and Embase. Associations found to be statistically significant were further classified into levels of evidence (convincing, suggestive, or weak), based on P value, between-study heterogeneity, prediction intervals, and small study effects. Sixty-four observational studies (case-control or cohort) corresponding to 154 effect sizes on the incidence of 25 types of cancer were included. Forty-three (27.9%) results in 15 different types of cancer were statistically significant. When combining all studies on the same type of cancer, 19 results in 11 different types of cancer showed significant associations with lower risk of gastrointestinal tract organ cancer (oral, gastric, colorectal, biliary tract, and liver cancer), breast cancer, and gynecological cancer (endometrial and ovarian cancer) as well as leukemia, lung cancer, and thyroid cancer. Only the reduced risk of oral cancer in tea-consuming populations (OR = 0.62; 95% CI: 0.55, 0.72; P value < 10-6) was supported by convincing evidence. Suggestive evidence was found for 6 results on biliary tract, breast, endometrial, liver, and oral cancer. To summarize, tea consumption was shown to have protective effects on some types of cancer, particularly oral cancer. More well-designed prospective studies are needed with consideration of other factors that can cause biases.
Filiaciones:
Kim TL:
Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
Jeong GH:
College of Medicine, Gyeongsang National University, Jinju, Korea
Yang JW:
Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju, Korea
Lee KH:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
Division of Pediatric Nephrology, Severance Children's Hospital, Seoul, Korea
Kronbichler A:
Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria
van der Vliet HJ:
Department of Medical Oncology, Amsterdam UMC, VU University, Cancer Center Amsterdam, Amsterdam, The Netherlands
Grosso G:
Department of Biomedical and Biotechnological Science, School of Medicine, University of Catania, Catania, Italy
Galvano F:
Department of Biomedical and Biotechnological Science, School of Medicine, University of Catania, Catania, Italy
Aune D:
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
Department of Nutrition, Bjørknes University College, Oslo, Norway
Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
Kim JY:
Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
Veronese N:
National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy
Stubbs B:
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
South London and Maudsley NHS Foundation Trust, London, UK
Positive Ageing Research Institute, Faculty of Health, Social Care, Medicine and Education, Anglia Ruskin University, Chelmsford, UK
Solmi M:
Department of Neuroscience, University of Padova, Padova, Italy
Koyanagi A:
Parc Sanitari Sant Joan de Déu/CIBERSAM, Universitat de Barcelona, Barcelona, Spain
ICREA, Barcelona, Spain
Hong SH:
Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Dragioti E:
Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
Cho E:
Department of Dermatology, The Warren Alpert Medical School, Brown University, Providence, RI, USA
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
de Rezende LFM:
Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina Preventiva, São Paulo, Brazil
Giovannucci EL:
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
Division of Pediatric Nephrology, Severance Children's Hospital, Seoul, Korea
Gamerith G:
Internal Medicine V, Department of Hematology & Oncology, Medical University Innsbruck, Innsbruck, Austria
Green Published, Bronze
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