Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis.


Por: Lee J, Son MJ, Son CY, Jeong GH, Lee KH, Lee KS, Ko Y, Kim JY, Lee JY, Radua J, Eisenhut M, Gressier F, Koyanagi A, Stubbs B, Solmi M, Rais TB, Kronbichler A, Dragioti E, Vasconcelos DFP, Silva FRPD, Tizaoui K, Brunoni AR, Carvalho AF, Cargnin S, Terrazzino S, Stickley A, Smith L, Thompson T, Shin JI and Fusar-Poli P

Publicada: 30 sep 2020 Ahead of Print: 30 sep 2020
Categoría: Neuroscience (miscellaneous)

Resumen:
This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.

Filiaciones:
Lee J:
 Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju 26426, Korea

Son MJ:
 Yonsei University College of Medicine, Seoul 03722, Korea

Son CY:
 Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, USA

Jeong GH:
 College of Medicine, Gyeongsang National University, Jinju 52727, Korea

Lee KH:
 Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Korea

Lee KS:
 Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea

Ko Y:
 Division of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do 17035, Korea

Kim JY:
 Yonsei University College of Medicine, Seoul 03722, Korea

Lee JY:
 Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Korea

Radua J:
 Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AB, UK

 Mental Health Networking Biomedical Research Centre (CIBERSAM), 08036 Barcelona, Spain

 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, 11330 Stockholm, Sweden

 Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain

Eisenhut M:
 Department of Pediatrics, Luton & Dunstable University Hospital NHS Foundation Trust, Luton LU4ODZ, UK

Gressier F:
 CESP, Inserm UMR1178, Department of Psychiatry, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, 94275 Le Kremlin Bicêtre, France

Koyanagi A:
 Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, CIBERSAM, 08830 Barcelona, Spain

 ICREA, Pg. Lluis Companys 23, 08010 Barcelona, Spain

 Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, 28029 Madrid, Spain

Stubbs B:
 Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London SE5 8AZ, UK

 Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK

Solmi M:
 Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AB, UK

 Department of Neurosciences, University of Padua, 90133 Padua, Italy

 Neurosciences Center, University of Padua, 90133 Padua, Italy

Rais TB:
 Department of Psychiatry, University of Toledo Medical Center, Toledo, OH 43614, USA

Kronbichler A:
 Department of Internal Medicine IV, Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria

Dragioti E:
 Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, SE-581 85 Linköping, Sweden

Vasconcelos DFP:
 Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of the Parnaiba Delta, Parnaiba 64202-020, Brazil

Silva FRPD:
 Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of the Parnaiba Delta, Parnaiba 64202-020, Brazil

Tizaoui K:
 Department of Basic Sciences, Medicine Faculty of Tunis, Tunis El Manar University, 15 Rue Djebel Lakdar, Tunis 1007, Tunisia

Brunoni AR:
 University Hospital, University of São Paulo, São Paulo CEP 05508-000, Brazil

 Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo CEP 01246-903, Brazil

 Laboratory of Neuroscience and National Institute of Biomarkers in Neuropsychiatry, Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo CEP 01246-903, Brazil

 Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 80336 Munich, Germany

Carvalho AF:
 Centre for Addiction & Mental Health, Toronto, ON M6J 1H4, Canada

 Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada

Cargnin S:
 Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, 28100 Novara, Italy

Terrazzino S:
 Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, 28100 Novara, Italy

Stickley A:
 The Stockholm Center for Health and Social Change (SCOHOST), Södertörn University, 141 89 Huddinge, Sweden

 Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo 187-8553, Japan

Smith L:
 The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK

Thompson T:
 Department of Psychology, University of Greenwich, London SE10 9LS, UK

Shin JI:
 Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Korea

Fusar-Poli P:
 Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AB, UK

 OASIS Service, South London and Maudsley NHS Foundation Trust, London SE8 5HA, UK

 Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
ISSN: 20763425
Editorial
MDPI, MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 10 Número: 10
Páginas:
WOS Id: 000584176700001
ID de PubMed: 33007889
imagen Green Published, gold, Green Accepted

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