Establishing Central Sensitization-Related Symptom Severity Subgroups: A Multicountry Study Using the Central Sensitization Inventory.
Por:
Cuesta Vargas A, Neblett R, Nijs J, Chiarotto A, Kregel J, van Wilgen CP, Pitance L, Knezevic A, Gatchel RJ, Mayer TG, Viti C, Roldan-Jiménez C, Testa M, Caumo W, Jeremic-Knezevic M, Nishigami T, Feliu A, Pérez A and Luciano JV
Publicada:
1 oct 2020
Resumen:
OBJECTIVES: The goal of this study was to identify central sensitization-related symptom severity subgroups in a large multicountry sample composed of patients with chronic pain and pain-free individuals using the Central Sensitization Inventory (CSI). METHODS: A large, pooled international (N = 8 countries) sample of chronic pain patients plus healthy subjects (total N = 2,620) was randomly divided into two subsamples for cross-validation purposes. First, a hierarchical cluster analysis (HCA) was performed using CSI item-level data as clustering variables (test sample; N = 1,312). Second, a latent profile analysis (LPA) was conducted to confirm the optimal number of CSI clusters (validation sample; N = 1,308). Finally, to promote implementation in real-world clinical practice, we built a free online Central Sensitization Inventory Symptom Severity Calculator. RESULTS: In both HCA (N = 1,219 valid cases) and LPA (N = 1,245 valid cases) analyses, a three-cluster and three-profile solution, respectively, emerged as the most statistically optimal and clinically meaningful. Clusters were labeled as follows: (i) Low Level of CS-Related Symptom Severity, (ii) Medium Level of CS-Related Symptom Severity, and (iii) High Level of CS-Related Symptom Severity. CONCLUSIONS: Our results indicated that a three-cluster solution clearly captured the heterogeneity of the CSI data. The calculator might provide an efficient way of classifying subjects into the cluster groups. Future studies should analyze the extent to which the CSI cluster classification correlates with other patient-reported and objective signs and symptoms of CS in patients with chronic pain, their associations with clinical outcomes, health-related costs, biomarkers, (etc.), and responsiveness to treatment.
Filiaciones:
Cuesta Vargas A:
Department of Physiotherapy of the Faculty of Health Science at the, University of Malaga, (IBIMA), Malaga, Spain
Faculty of Health at the Queensland University of Technology, Brisbane, Australia
Neblett R:
PRIDE Research Foundation, Dallas, Texas, USA
Nijs J:
Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Pain in Motion International Research Group, Vrije Universiteit Brussel, Brussels, Belgium
Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Brussels, Belgium
Chiarotto A:
Department of Health Sciences, Amsterdam Movement Sciences Research Institute, VU University, Amsterdam, the Netherlands
Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
Kregel J:
Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
Pain in Motion International Research Group, Vrije Universiteit, Brussels, Belgium
van Wilgen CP:
Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Pain in Motion International Research Group, Vrije Universiteit Brussel, Brussels, Belgium
Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Brussels, Belgium
Transcare, Transdisciplinary Pain Center, the Netherlands
Pitance L:
Neuro Musculoskeletal Lab, Institute of Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium
Department of Oral and Maxillofacial Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
Knezevic A:
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Medical Rehabilitation Clinic, Clinical Centre of Vojvodina, Novi Sad, Serbia
Gatchel RJ:
Pain in Motion International Research Group, Vrije Universiteit, Brussels, Belgium
Department of Psychology, College of Science, University of Texas, Arlington, Texas, USA
Mayer TG:
Department of Orthopedic Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Viti C:
FACEit, Italian Association of Integrated Therapy for Cervico-Cranio-Facial Pain and Dysfunction, Barlassina, Italy
Department of Biomedical Sciences, University of Padova, Padova, Italy
Studio Fisioterapico Viti, Bologna, Italy
Roldan-Jiménez C:
Department of Physiotherapy of the Faculty of Health Science at the, University of Malaga, (IBIMA), Malaga, Spain
Testa M:
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Campus of Savona, Savona, Italy
Caumo W:
Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
Pain and Palliative Care Service at Hospital de Clínicas de Porto Alegre (HCPA), Laboratory of Pain and Neuromodulation at UFRGS, Porto Alegre, Brazil
Pain and Anesthesia in Surgery Department, School of Medicine, UFRGS, Porto Alegre, Brazil
Jeremic-Knezevic M:
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Nishigami T:
Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, Hiroshima, Japan
Feliu A:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, St. Boi de Llobregat, Spain
Pérez A:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, St. Boi de Llobregat, Spain
Luciano JV:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, St. Boi de Llobregat, Spain
Green Published, Bronze
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