Tuberculosis and Non-Communicable Disease Multimorbidity: An Analysis of the World Health Survey in 48 Low- and Middle-Income Countries.
Por:
Stubbs B, Siddiqi K, Elsey H, Siddiqi N, Ma R, Romano E, Siddiqi S and Koyanagi A
Publicada:
2 mar 2021
Ahead of Print:
2 mar 2021
Categoría:
Health, toxicology and mutagenesis
Resumen:
Tuberculosis (TB) is a leading cause of mortality in low- and middle-income countries (LMICs). TB multimorbidity [TB and =1 non-communicable diseases (NCDs)] is common, but studies are sparse. Cross-sectional, community-based data including adults from 21 low-income countries and 27 middle-income countries were utilized from the World Health Survey. Associations between 9 NCDs and TB were assessed with multivariable logistic regression analysis. Years lived with disability (YLDs) were calculated using disability weights provided by the 2017 Global Burden of Disease Study. Eight out of 9 NCDs (all except visual impairment) were associated with TB (odds ratio (OR) ranging from 1.38-4.0). Prevalence of self-reported TB increased linearly with increasing numbers of NCDs. Compared to those with no NCDs, those who had 1, 2, 3, 4, and =5 NCDs had 2.61 (95% confidence interval (CI) = 2.14-3.22), 4.71 (95%CI = 3.67-6.11), 6.96 (95%CI = 4.95-9.87), 10.59 (95%CI = 7.10-15.80), and 19.89 (95%CI = 11.13-35.52) times higher odds for TB. Among those with TB, the most prevalent combinations of NCDs were angina and depression, followed by angina and arthritis. For people with TB, the YLDs were three times higher than in people without multimorbidity or TB, and a third of the YLDs were attributable to NCDs. Urgent research to understand, prevent and manage NCDs in people with TB in LMICs is needed.
Filiaciones:
Stubbs B:
Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AB, UK
Siddiqi K:
Department of Health Sciences, The University of York, York YO10 5DD, UK
Hull York Medical School, The University of York, York YO10 5DD, UK
Elsey H:
Department of Health Sciences, The University of York, York YO10 5DD, UK
Hull York Medical School, The University of York, York YO10 5DD, UK
Siddiqi N:
Department of Health Sciences, The University of York, York YO10 5DD, UK
Hull York Medical School, The University of York, York YO10 5DD, UK
Ma R:
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AB, UK
Romano E:
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AB, UK
Siddiqi S:
Department of Community Health Sciences, Aga Khan University, Karachi 74800, Pakistan
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, 08830 Barcelona, Spain
ICREA, Pg. Lluis Companys 23, 08010 Barcelona, Spain
gold, Green Published, Green Accepted
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