Vaccines and allergic reactions: The past, the current COVID-19 pandemic, and future perspectives.
Por:
Sampath V, Rabinowitz G, Shah M, Jain S, Diamant Z, Jesenak M, Rabin R, Vieths S, Agache I, Akdis M, Barber D, Breiteneder H, Chinthrajah S, Chivato T, Collins W, Eiwegger T, Fast K, Fokkens W, O'Hehir RE, Ollert M, O'Mahony L, Palomares O, Pfaar O, Riggioni C, Shamji MH, Sokolowska M, Torres MJ, Traidl-Hoffmann C, van Zelm M, Wang Y, Zhang L, Akdis C and Nadeau KC
Publicada:
4 jun 2021
Ahead of Print:
4 jun 2021
Resumen:
Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.
Filiaciones:
Sampath V:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA
Rabinowitz G:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA
Shah M:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA
Jain S:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA
Diamant Z:
Dept of Microbiology Immunology & Transplantation, KU Leuven, Catholic University of Leuven, Belgium
Dept of Respiratory Medicine & Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden
Dept Clin Pharm &Pharmacol, Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands
Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
Jesenak M:
Department of Pediatrics and Department of Clinical Immunology and Allergology, Center for Vaccination in Special Situations, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital in Martin, Slovakia
Rabin R:
Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA
Vieths S:
Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany
Agache I:
Transylvania University, Brasov, Romania
Akdis M:
Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Switzerland
Barber D:
Facultad de Medicina, Departamento de CienciasMédicasBásicas, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities, Madrid, España. RETIC ARADYAL. Instituto de Salud Carlos III, Spain
Breiteneder H:
Division of Medical Biotechnology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
Chinthrajah S:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Chivato T:
School of Medicine, University CEU San Pablo. Madrid, Spain
Collins W:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA
Division of Hospital Medicine, Department of Medicine, Stanford, CA, USA
Eiwegger T:
Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Toronto, ON, Canada
Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Department of Immunology, University of Toronto, Toronto, ON, Canada
Fast K:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA
Fokkens W:
Amsterdam University Medical Centers, location AMC, department of otorhinolaryngology, Amsterdam, Netherlands
O'Hehir RE:
Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University, and Alfred Health, Melbourne, Victoria, Australia
Ollert M:
Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg and Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, Odense University Hospital, University of Southern Denmark, Odense, Denmark
O'Mahony L:
Department of Medicine and School of Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland
Palomares O:
Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University, Madrid, Spain
Pfaar O:
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
:
Allergy and Clinical Immunology, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Shamji MH:
Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, Imperial College London, London, United Kingdom and Centre in Allergic Mechanisms of Asthma, London, United Kingdom
Sokolowska M:
Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Switzerland
Torres MJ:
Allergy Unit, Malaga Regional University Hospital-UMA-ARADyAL, Málaga, Spain
Traidl-Hoffmann C:
Department of environmental medicine, Medical Faculty, University Augsburg, Augsburg, Germany
Institute of environmental medicine, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany
van Zelm M:
Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia and Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, VIC, Australia
Wang Y:
Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Zhang L:
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730, P.R. China
Akdis C:
Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Switzerland
Nadeau KC:
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Green Published, Bronze, Green Submitted
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