Antibacterial Properties of Triethoxysilylpropyl Succinic Anhydride Silane (TESPSA) on Titanium Dental Implants.
Por:
Buxadera J, Godoy-Gallardo M, Molmeneu M, Punset M and Gil FJ
Publicada:
1 abr 2020
Ahead of Print:
1 abr 2020
Resumen:
Infections related to dental implants are a common complication that can ultimately lead to implant failure, and thereby carries significant health and economic costs. In order to ward off these infections, this paper explores the immobilization of triethoxysilylpropyl succinic anhydride (TESPSA, TSP) silane onto dental implants, and the interaction of two distinct monospecies biofilms and an oral plaque with the coated titanium samples. To this end, titanium disks from prior machining were first activated by a NaOH treatment and further functionalized with TESPSA silane. A porous sodium titanate surface was observed by scanning electron microscopy and X-ray photoelectron spectroscopy analyses confirmed the presence of TESPSA on the titanium samples (8.4% for Ti-N-TSP). Furthermore, a lactate dehydrogenase assay concluded that TESPSA did not have a negative effect on the viability of human fibroblasts. Importantly, the in vitro effect of modified surfaces against Streptococcus sanguinis, Lactobacillus salivarius and oral plaque were studied using a viable bacterial adhesion assay. A significant reduction was achieved in all cases but, as expected, with different effectiveness against simple mono-species biofilm (ratio dead/live of 0.4) and complete oral biofilm (ratio dead/live of 0.6). Nevertheless, this approach holds a great potential to provide dental implants with antimicrobial properties.
Filiaciones:
Buxadera J:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Av. Eduard Maristany, 10-14, 08019 Barcelona, Spain
Barcelona Research Centre in Multiscale Science and Engineering, Technical University of Catalonia (UPC), Av. Eduard Maristany, 10-14, 08019 Barcelona, Spain
Godoy-Gallardo M:
Bioengineering Institute of Technology (BIT), Universitat Internacional de Catalunya (UIC), C. Josep Trueta s/n, 08195 Sant Cugat del Vallès, Spain
Basic Science Department, Faculty of Medicine and Health Science, Universitat Internacional de Catalunya (UIC), C. Josep Trueta s/n, 08195 Sant Cugat del Vallès, Spain
Molmeneu M:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Av. Eduard Maristany, 10-14, 08019 Barcelona, Spain
Barcelona Research Centre in Multiscale Science and Engineering, Technical University of Catalonia (UPC), Av. Eduard Maristany, 10-14, 08019 Barcelona, Spain
Punset M:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Av. Eduard Maristany, 10-14, 08019 Barcelona, Spain
Barcelona Research Centre in Multiscale Science and Engineering, Technical University of Catalonia (UPC), Av. Eduard Maristany, 10-14, 08019 Barcelona, Spain
UPC Innovation and Technology Center (CIT-UPC), Technical University of Catalonia (UPC), C. Jordi Girona 3-1, 08034 Barcelona, Spain
Gil FJ:
Bioengineering Institute of Technology (BIT), Universitat Internacional de Catalunya (UIC), C. Josep Trueta s/n, 08195 Sant Cugat del Vallès, Spain
School of Dentistry, Faculty of Medicine and Health Science, Universitat Internacional de Catalunya (UIC), C. Josep Trueta s/n, 08195 Sant Cugat del Vallès, Spain
Open Access
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