Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners.
Por:
Campderrós L, Sánchez-Infantes D, Villarroya-Terrade J, Nescolarde L, Bayès-Genis A, Cereijo R, Roca E and Villarroya-Gombau F
Publicada:
19 nov 2020
Ahead of Print:
19 nov 2020
Resumen:
BACKGROUND: Recreational marathon runners face strong physiological challenges. Assessment of potential biomarkers for the biological responses of runners will help to discriminate individual race responsiveness and their physiological consequences. This study sought to analyze the changes in the plasma levels of GDF15 and FGF21, novel endocrine factors related to metabolic stress, in runners following the strenuous exercise of a marathon race. METHODS: Blood samples were obtained from eighteen male runners (mean ±SD, age: 41.7 ±5.0 years, BMI: 23.6 ± 1.8) 48 h before, immediately after, and 48 h after a marathon race, and from age-matched sedentary individuals. The level of GDF15, FGF21, and 38 additional biochemical and hematological parameters were determined. RESULTS: The basal levels of GDF15 and FGF21 did not differ between runners before the race and sedentary individuals. Significant increases in the mean levels of GDF15 (4.2-fold) and FGF21 (20-fold) were found in runners immediately after the race. The magnitudes of these increases differed markedly among individuals and did not correlate with each other. The GDF15 and FGF21 levels had returned to the basal level 48 h post-race. The post-race value of GDF15 (but not FGF21) correlated positively with increased total white cell count (r = 0.50, P = 0.01) and neutrophilia (r = 0.10, P = 0.01). CONCLUSION: GDF15 and FGF21 are transiently increased in runners following a marathon race. The induction of GDF15 levels is associated with alterations in circulating immune cells levels.
Filiaciones:
Campderrós L:
Departament de Bioquimica i Biomedicina Molecular, University of Barcelona, Barcelona, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Madrid, Spain
Sánchez-Infantes D:
CIBER Fisiopatología de la Obesidad y Nutrición, Madrid, Spain
Institut de Recerca Germans Trias i Pujol, Barcelona, Spain
Villarroya-Terrade J:
Departament de Bioquimica i Biomedicina Molecular, University of Barcelona, Barcelona, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Madrid, Spain
Nescolarde L:
Research Centre for Biomedical Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain
Department of Electronic Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain
Bayès-Genis A:
Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
CIBER de Enfermedades Cardiovasculares, Madrid, Spain
Cereijo R:
Departament de Bioquimica i Biomedicina Molecular, University of Barcelona, Barcelona, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Madrid, Spain
Roca E:
Research Centre for Biomedical Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain
Villarroya-Gombau F:
Departament de Bioquimica i Biomedicina Molecular, University of Barcelona, Barcelona, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Madrid, Spain
Open Access
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