Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
Por:
Jacob L., Kostev K, Smith L, Hans Oh, López-Sánchez GF, Shin JI, Abduljabbar AS, Haro JM and Koyanagi A
Publicada:
1 ene 2021
Ahead of Print:
28 jun 2021
Resumen:
BACKGROUND: Little is known about the relationship between sarcopenia and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). OBJECTIVE: This study aimed to investigate this association among community-dwelling adults aged=65 years from six LMICs. METHODS: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. These data were obtained in China, Ghana, India, Mexico, Russia, and South Africa in 2007-2010. Participants were considered to have sarcopenia if they had low skeletal muscle mass (i.e., lower skeletal mass index) and a weak handgrip strength. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Multivariable logistic regression analysis was conducted to assess associations. RESULTS: The final analytical sample consisted of 12,912 individuals aged=65 years with preservation in functional abilities without stroke (mean [standard deviation] age 72.2 [10.8] years; 45.2% males). The overall prevalence of sarcopenia and MCI were 11.3% and 18.1%, respectively. After adjusting for potential confounders, there was a positive association between sarcopenia and MCI in all countries (i.e., odds ratio [OR] > 1) with the exception of South Africa, and the overall estimate was OR = 1.60 (95% confidence interval [CI] = 1.32-1.93) with a low level of between-country heterogeneity (I2 = 0.0%). CONCLUSION: There was a positive association between sarcopenia and MCI in this sample of older adults living in LMICs. Causality should be assessed in future longitudinal research, while the utility of sarcopenia as a marker of MCI should also be investigated.
Filiaciones:
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France
Kostev K:
Philipps University of Marburg, Marburg, Germany
Smith L:
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK
Hans Oh:
Suzanne Dworak Peck School of Social Work, University of Southern California, Los Angeles, CA, USA
López-Sánchez GF:
Vision and Eye Research Institute, School of Medicine, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University-Cambridge Campus, Cambridge, UK
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
Abduljabbar AS:
King Saud University, Riyadh, Saudi Arabia
Haro JM:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
King Saud University, Riyadh, Saudi Arabia
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
ICREA, Barcelona, Spain
Green Accepted
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