Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis.
Por:
Serra-Blasco M, Radua J, Soriano-Mas C, Gómez-Benlloch A, Porta-Casteràs D, Marta Carulla Roig, Albajes-Eizagirre A, Arnone D, Klauser P, Canales-Rodríguez EJ, Hilbert K, Wise T, Cheng Y, Kandilarova S, Mataix-Cols D, Vieta E, Via E and Cardoner N
Publicada:
1 oct 2021
Ahead of Print:
10 jul 2021
Resumen:
The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.
Filiaciones:
Serra-Blasco M:
Mental Health Department, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT), Spain
Department of Psychology, Abat Oliba CEU University, Spain
Programa E-Health ICOnnecta't, Institut Català d'Oncologia, Barcelona, Spain
Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM), Spain
Radua J:
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain
Early Psychosis: Interventions and Clinical-detection (EPIC) lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom
Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, Spain
Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM), Spain
Soriano-Mas C:
Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, Department of Psychiatry, Bellvitge University Hospital, Spain
Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona, Spain
Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM), Spain
Gómez-Benlloch A:
Hospital General de Granollers, Spain
Porta-Casteràs D:
Mental Health Department, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT), Spain
Marta Carulla Roig:
Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain
Albajes-Eizagirre A:
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain
Arnone D:
Department of Psychiatry and Behavioral Science, College of Medicine and Health Sciences, United Arab Emirates University (UAEU), United Arab Emirates
Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Klauser P:
Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland
Department of Psychiatry, Service of Child and Adolescent Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland
Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Australia
Canales-Rodríguez EJ:
FIDMAG Research Foundation, Germanes Hospitalàries, Spain
Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM), Spain
Hilbert K:
Humboldt-Universität zu Berlin, Department of Psychology, Berlin, Germany
Wise T:
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London & Division of the Humanities and Social Sciences, California Institute of Technology, Caltech, United States
Cheng Y:
Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China
Kandilarova S:
Department of Psychiatry and Medical Psychology, and Research Institute at Medical University of Plovdiv, Bulgaria
Mataix-Cols D:
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden
Vieta E:
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain
Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, Spain
Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM), Spain
Via E:
Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain
Cardoner N:
Mental Health Department, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT), Spain
Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Spain
Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM), Spain
Green Published, Green Accepted
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