The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study
Por:
Brotons-de los Reyes P, Jordán-García I, Bassat Q, Henares-Bonilla D, Fernández de Sevilla-Estrach M, Ajanovic S, Redin-Alonso A, Fumadó V, Baro B, Claverol J, Varo R, Cuadras-Palleja D, Hecht J, Barrabeig I, García-García JJ, Launes-Montana C and Munoz-Almagro C
Publicada:
1 ago 2021
Ahead of Print:
12 ago 2021
Categoría:
Infectious diseases
Resumen:
We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.
Filiaciones:
Brotons-de los Reyes P:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Department of Medicine, School of Medicine, Universitat Internacional de Catalunya, Sant Cugat, 08195 Barcelona, Spain
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Jordán-García I:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Bassat Q:
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Pediatrics Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Centro de Investigação em Saúde de Manhiça (CISM), Manhiça 1929, Mozambique
ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain
Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain
Henares-Bonilla D:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Fernández de Sevilla-Estrach M:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Pediatrics Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Ajanovic S:
ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain
Redin-Alonso A:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Department of Medicine, School of Medicine, Universitat Internacional de Catalunya, Sant Cugat, 08195 Barcelona, Spain
Fumadó V:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Pediatrics Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Baro B:
ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain
Claverol J:
Clinical Research Unit, Fundació Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
:
ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain
Cuadras-Palleja D:
Clinical Research Unit, Fundació Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Hecht J:
Centre for Genomic Regulation (CRG), Genomics Unit, 08003 Barcelona, Spain
Barrabeig I:
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Epidemiological Surveillance Unit, Department of Health, Generalitat de Catalunya, 08907 Barcelona, Spain
García-García JJ:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Pediatrics Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Launes-Montana C:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Pediatrics Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Munoz-Almagro C:
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Department of Medicine, School of Medicine, Universitat Internacional de Catalunya, Sant Cugat, 08195 Barcelona, Spain
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
Department of Molecular Epidemiology, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
Green Published, Green Submitted, gold
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