Sleep problems and mild cognitive impairment among adults aged =50 years from low- and middle-income countries.
Por:
Smith L, Shin JI, Jacob L., Carmichael C, López Sánchez GF, Hans Oh, Butler LT, Barnett Y, Pizzol D, Tully MA, Soysal P, Veronese N and Koyanagi A
Publicada:
15 oct 2021
Ahead of Print:
10 ago 2021
Resumen:
BACKGROUND: The limited available literature suggests that sleep problems are linked to an increased risk of mild cognitive impairment (MCI). However, this association has been little studied to date in low-income settings. OBJECTIVE: To investigate the association between sleep problems and MCI in a large sample of adults from six low-and middle-income countries (LMICs). DESIGN: Cross-sectional. SETTING: Study on Global Ageing and Adult Health (SAGE). SUBJECTS: 32,715 individuals aged =50 years with preservation in functional abilities [age range 50-114 years; 51.7% females]. METHODS: MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Sleep problems were assessed by the question "Overall in the last 30 days, how much of a problem did you have with sleeping, such as falling asleep, waking up frequently during the night or waking up too early in the morning?" and categorized as "None", "Mild", "Moderate", "Severe/Extreme". Multivariable logistic regression analysis and meta-analysis were conducted. RESULTS: Compared to no sleep problems, mild, moderate, and severe/extreme sleep problems were associated with significant 1.40, 1.83, and 2.69 times higher odds for MCI with similar associations being observed between age groups and sex. Severe/extreme sleep problems were positively associated with MCI (i.e., OR > 1) in the six countries studied with the overall estimate being OR = 1.80 (95% CI = 1.50-2.16), and a low level of between-country heterogeneity was observed (I(2) = 28.2%). CONCLUSIONS: Sleep problems were associated with higher odds for MCI. Interventions to improve sleep quality among middle-aged and older adults in LMICs may be an effective strategy in reducing risk of MCI and dementia.
Filiaciones:
Smith L:
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux 78180, France
Carmichael C:
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
López Sánchez GF:
Vision and Eye Research Institute, School of Medicine, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Cambridge, UK
Hans Oh:
Suzanne Dworak Peck School of Social Work, University of Southern California, Los Angeles, CA 90007, USA
Butler LT:
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Barnett Y:
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Pizzol D:
Italian Agency for Development Cooperation - Khartoum, Sudan
Tully MA:
School of Health Sciences, Institute of Mental Health Sciences, Ulster University, Newtownabbey BT15 1ED, Northern Ireland, UK
Soysal P:
Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvari (Vatan Street), 34093 Fatih, Istanbul, Turkey
Veronese N:
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, Italy
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain
ICREA, Pg, Lluis Companys 23, 08010 Barcelona, Spain
Green Accepted, Green Submitted
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