Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
Por:
Fuentes-Claramonte P, Soler-Vidal J, Salgado-Pineda P, García-León MÁ, Ramiro N, Santo-Angles A, Llanos Torres M, Tristany J, Guerrero-Pedraza A, Munuera-del Cerro JL, Sarró S, Salvador R, Hinzen W, McKenna PJ and Pomarol-Clotet E
Publicada:
23 sep 2021
Ahead of Print:
23 sep 2021
Categoría:
Multidisciplinary
Resumen:
Auditory verbal hallucinations (AVH, 'hearing voices') are an important symptom of schizophrenia but their biological basis is not well understood. One longstanding approach proposes that they are perceptual in nature, specifically that they reflect spontaneous abnormal neuronal activity in the auditory cortex, perhaps with additional 'top down' cognitive influences. Functional imaging studies employing the symptom capture technique-where activity when patients experience AVH is compared to times when they do not-have had mixed findings as to whether the auditory cortex is activated. Here, using a novel variant of the symptom capture technique, we show that the experience of AVH does not induce auditory cortex activation, even while real speech does, something that effectively rules out all theories that propose a perceptual component to AVH. Instead, we find that the experience of AVH activates language regions and/or regions that are engaged during verbal short-term memory.
Filiaciones:
Fuentes-Claramonte P:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain
CIBERSAM, Madrid, Spain
Soler-Vidal J:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain
CIBERSAM, Madrid, Spain
Universitat de Barcelona, Barcelona, Spain
Benito Menni Complex Asistencial en Salut Mental, Sant Boi de Llobregat, Spain
Salgado-Pineda P:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain
CIBERSAM, Madrid, Spain
García-León MÁ:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain
CIBERSAM, Madrid, Spain
Ramiro N:
Hospital de Sant Rafael, Barcelona, Spain
Santo-Angles A:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain
Llanos Torres M:
Hospital Mare de Déu de la Mercè, Barcelona, Spain
Tristany J:
Hospital Sagrat Cor de Martorell, Barcelona, Spain
Guerrero-Pedraza A:
Benito Menni Complex Asistencial en Salut Mental, Sant Boi de Llobregat, Spain
Munuera-del Cerro JL:
Hospital de Sant Joan de Déu, Barcelona, Spain
Sarró S:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain
CIBERSAM, Madrid, Spain
Salvador R:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain
CIBERSAM, Madrid, Spain
Hinzen W:
ICREA (Institució Catalana de Recerca i Estudis Avançats), Barcelona, Spain
Universitat Pompeu Fabra, Barcelona, Spain
McKenna PJ:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain.
CIBERSAM, Madrid, Spain.
Pomarol-Clotet E:
FIDMAG Hermanas Hospitalarias Research Foundation, C/. Dr. Antoni Pujadas 38, 08830, Sant Boi de Llobregat, Barcelona, Spain
CIBERSAM, Madrid, Spain
Green Published, gold
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