Lower Respiratory Tract Infection and Genus Enterovirus in Children Requiring Intensive Care: Clinical Manifestations and Impact of Viral Co-Infections
Por:
Penela-Sánchez D, González-de-Audicana J, Armero-Campos G, Henares-Bonilla D, Esteva-Afonso C, Fernández de Sevilla-Estrach M, Ricart S, Jordán-García I, Brotons-de los Reyes P, Cabrerizo M, Munoz-Almagro C and Launes-Montana C
Publicada:
1 oct 2021
Ahead of Print:
14 oct 2021
Categoría:
Infectious diseases
Resumen:
Infection by rhinovirus (RV) and enterovirus (EV) in children ranges
from asymptomatic infection to severe lower respiratory tract infection
(LRTI). This cohort study evaluates the clinical impact of RV/EV
species, alone or in codetection with other viruses, in young children
with severe LRTI. Seventy-one patients aged less than 5 years and
admitted to the Paediatric Intensive Care Unit (PICU) of a reference
children's hospital with RV or EV (RV/EV) LRTI were prospectively
included from 1/2018 to 3/2020. A commercial PCR assay for multiple
respiratory pathogens was performed in respiratory specimens. In 22/71,
RV/EV + respiratory syncytial virus (RSV) was found, and 18/71 had RV/EV
+ multiple viral detections. Patients with single RV/EV detection
required invasive mechanical ventilation (IMV) as frequently as those
with RSV codetection, whereas none of those with multiple viral
codetections required IMV. Species were determined in 60 samples, 58
being RV. No EV-A, EV-C, or EV-D68 were detected. RV-B and EV-B were
only found in patients with other respiratory virus codetections. There
were not any associations between RV/EV species and severity outcomes.
To conclude, RV/EV detection alone was observed in young children with
severe disease, while multiple viral codetections may result in reduced
clinical severity. Differences in pathogenicity between RV and EV
species could not be drawn.
Filiaciones:
:
Paediatrics Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Paediatrics Intensive Care Unit, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
González-de-Audicana J:
Enterovirus and Viral Gastroenteritis Unit, Centro Nacional de Microbiología, Instituto Carlos III, 28222 Madrid, Spain
Armero-Campos G:
Paediatrics Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Paediatrics Intensive Care Unit, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Henares-Bonilla D:
Grupo de Investigación en Enfermedades Infecciosas Pediátricas, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Molecular Microbiology Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
Esteva-Afonso C:
Grupo de Investigación en Enfermedades Infecciosas Pediátricas, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Molecular Microbiology Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Fernández de Sevilla-Estrach M:
Paediatrics Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Grupo de Investigación en Enfermedades Infecciosas Pediátricas, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
Paediatrics Department, Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08007 Barcelona, Spain
Ricart S:
Paediatrics Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Paediatrics Department, Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08007 Barcelona, Spain
Jordán-García I:
Paediatrics Intensive Care Unit, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Grupo de Investigación en Enfermedades Infecciosas Pediátricas, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
Paediatrics Department, Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08007 Barcelona, Spain
Brotons-de los Reyes P:
Grupo de Investigación en Enfermedades Infecciosas Pediátricas, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
Department of Medicine, School of Medicine, Universitat Internacional de Catalunya, 08017 Barcelona, Spain
Cabrerizo M:
Enterovirus and Viral Gastroenteritis Unit, Centro Nacional de Microbiología, Instituto Carlos III, 28222 Madrid, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
Munoz-Almagro C:
Grupo de Investigación en Enfermedades Infecciosas Pediátricas, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Molecular Microbiology Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
Department of Medicine, School of Medicine, Universitat Internacional de Catalunya, 08017 Barcelona, Spain
Launes-Montana C:
Paediatrics Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Grupo de Investigación en Enfermedades Infecciosas Pediátricas, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
Paediatrics Department, Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08007 Barcelona, Spain
Green Submitted, gold
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