Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
Por:
Folle, C, Marques, AM, Diaz-Garrido, N, Espina, M, Sanchez-Lopez, E, Badia-Palacin J, Baldoma L, Calpena, AC and Garcia, ML
Publicada:
8 nov 2021
Ahead of Print:
8 nov 2021
Resumen:
Background: Acne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason, we developed polymeric nanoparticles encapsulating thymol, a natural active compound with antimicrobial and antioxidant properties. In this work, optimization physicochemical characterization, biopharmaceutical behavior and therapeutic efficacy of this novel nanostructured system were assessed.
Results: Thymol NPs ( TH-NP) resulted on suitable average particle size below 200 nm with a surface charge around - 28 mV and high encapsulation efficiency (80%). TH-NP released TH in a sustained manner and provide a slow-rate penetration into the hair follicle, being highly retained inside the skin. TH-NP possess a potent antimicrobial activity against Cutibacterium acnes and minor effect towards Staphylococcus epidermis, the major resident of the healthy skin microbiota. Additionally, the stability and sterility of developed NPs were maintained along storage.
Conclusion: TH-NP showed a promising and efficient alternative for the treatment of skin acne infection, avoiding antibiotic administration, reducing side effects, and preventing microbial drug resistance, without altering the healthy skin microbiota. Additionally, TH-NP enhanced TH antioxidant activity, constituting a natural, preservative-free, approach for acne treatment.
Filiaciones:
Folle, C:
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain
Marques, AM:
Department of Biology, Healthcare and Environment, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain
Diaz-Garrido, N:
Department of Biochemistry and Physiology, Biochemistry and Biomolecular Science, University of Barcelona, 08028, Barcelona, Spain
Institute of Biomedicine of the University of Barcelona (IBUB), 08028, Barcelona, Spain
Research Institute Sant Joan De Déu (IR-SJD), 08950, Barcelona, Spain
Espina, M:
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028, Barcelona, Spain
Sanchez-Lopez, E:
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028, Barcelona, Spain.
Badia-Palacin J:
Department of Biochemistry and Physiology, Biochemistry and Biomolecular Science, University of Barcelona, 08028, Barcelona, Spain
Institute of Biomedicine of the University of Barcelona (IBUB), 08028, Barcelona, Spain
Research Institute Sant Joan De Déu (IR-SJD), 08950, Barcelona, Spain
Baldoma L:
Department of Biochemistry and Physiology, Biochemistry and Biomolecular Science, University of Barcelona, 08028, Barcelona, Spain
Institute of Biomedicine of the University of Barcelona (IBUB), 08028, Barcelona, Spain
Research Institute Sant Joan De Déu (IR-SJD), 08950, Barcelona, Spain
Calpena, AC:
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028, Barcelona, Spain
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