Impact of data extraction errors in meta-analyses on the association between depression and peripheral inflammatory biomarkers: an umbrella review.
Por:
Lee S, Lee KH, Park KM, Park SJ, Kim WJ, Lee J, Kronbichler A, Smith L, Solmi M, Stubbs B, Koyanagi A, Jacob L., Stickley A, Thompson T, Dragioti E, Hans Oh, Brunoni AR, Carvalho AF, Radua J, An SK, Namkoong K, Lee E, Shin JI and Fusar-Poli P
Publicada:
1 abr 2023
Ahead of Print:
9 nov 2021
Resumen:
BACKGROUND: Accumulating evidence suggests that alterations in inflammatory biomarkers are important in depression. However, previous meta-analyses disagree on these associations, and errors in data extraction may account for these discrepancies. METHODS: PubMed/MEDLINE, Embase, PsycINFO, and the Cochrane Library were searched from database inception to 14 January 2020. Meta-analyses of observational studies examining the association between depression and levels of tumor necrosis factor-a (TNF-a), interleukin 1-ß (IL-1ß), interleukin-6 (IL-6), and C-reactive protein (CRP) were eligible. Errors were classified as follows: incorrect sample sizes, incorrectly used standard deviation, incorrect participant inclusion, calculation error, or analysis with insufficient data. We determined their impact on the results after correction thereof. RESULTS: Errors were noted in 14 of the 15 meta-analyses included. Across 521 primary studies, 118 (22.6%) showed the following errors: incorrect sample sizes (20 studies, 16.9%), incorrect use of standard deviation (35 studies, 29.7%), incorrect participant inclusion (7 studies, 5.9%), calculation errors (33 studies, 28.0%), and analysis with insufficient data (23 studies, 19.5%). After correcting these errors, 11 (29.7%) out of 37 pooled effect sizes changed by a magnitude of more than 0.1, ranging from 0.11 to 1.15. The updated meta-analyses showed that elevated levels of TNF- a, IL-6, CRP, but not IL-1ß, are associated with depression. CONCLUSIONS: These findings show that data extraction errors in meta-analyses can impact findings. Efforts to reduce such errors are important in studies of the association between depression and peripheral inflammatory biomarkers, for which high heterogeneity and conflicting results have been continuously reported.
Filiaciones:
Lee S:
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea
Lee KH:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea
Park KM:
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea
Park SJ:
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Kim WJ:
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Lee J:
Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
Kronbichler A:
Department of Medicine, University of Cambridge, Cambridge, UK
Smith L:
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK
Solmi M:
Department of Psychiatry, University of Ottawa, Ontario, Canada
Department of Mental Health, The Ottawa Hospital, Ontario, Canada
Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program, University of Ottawa, Ontario, Canada
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychosis Studies, King's College London, London, UK
Stubbs B:
Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK
Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK
Koyanagi A:
Parc Sanitari Sant Joan de Deu/CIBERSAM, Universitat de Barcelona, Fundacio Sant Joan de Deu, Sant Boi de Llobregat, Barcelona, Spain
ICREA, Pg. Lluís Companys 23, Barcelona, Spain
Jacob L.:
Parc Sanitari Sant Joan de Deu/CIBERSAM, Universitat de Barcelona, Fundacio Sant Joan de Deu, Sant Boi de Llobregat, Barcelona, Spain
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France
Stickley A:
Stockholm Center for Health and Social Change (SCOHOST), Södertörn University, Huddinge141 89, Sweden
Thompson T:
Department of Psychology, University of Greenwich, LondonSE109LS, UK
Dragioti E:
Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linköping University, SE-581 85 Linköping, Sweden
Hans Oh:
School of Social Work, University of Southern California, CA, USA
Brunoni AR:
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Department of Psychiatry, Service of Interdisciplinary Neuromodulation, Laboratory of Neurosciences (LIM-27) and National Institute of Biomarkers in Neuropsychiatry (INBioN), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
Departamento de Clínica Médica, Hospital Universitario, Faculdade de Medicina da USP, São Paulo, Brazil
Carvalho AF:
Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada
Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Radua J:
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychosis Studies, King's College London, London, UK
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institute, Stockholm, Sweden
Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain
An SK:
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Namkoong K:
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Lee E:
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea
Fusar-Poli P:
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychosis Studies, King's College London, London, UK
OASIS service, South London and Maudsley NHS Foundation Trust, London, UK
Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy
Green Accepted
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