Antibody conversion rates to SARS-CoV-2 in saliva from children attending summer schools in Barcelona, Spain
Por:
Dobaño C, Alonso S, Fernández de Sevilla-Estrach M, Vidal M, Jiménez A, Pons Tomas G, Jairoce C, Melé Casas M, Rubio R, Hernández García M, Ruiz-Olalla G, Girona M, Barrios D, Santano R, Mitchell RA, Puyol L, Mayer L, Chi J, Rodrigo Melero N, Carolis C, Garcia-Miquel A, Bonet-Carne E, Claverol J, Cubells M, Fortuny-Guasch C, Fumadó V, Jou-Munoz C, Munoz-Almagro C, Izquierdo L, Bassat Q, Gratacós E, Aguilar R, García-García JJ, Moncunill G and Jordán-García I
Publicada:
23 nov 2021
Ahead of Print:
23 nov 2021
Categoría:
Medicine (miscellaneous)
Resumen:
Background Surveillance tools to estimate viral transmission dynamics in young populations are essential to guide recommendations for school opening and management during viral epidemics. Ideally, sensitive techniques are required to detect low viral load exposures among asymptomatic children. We aimed to estimate SARS-CoV-2 infection rates in children and adult populations in a school-like environment during the initial COVID-19 pandemic waves using an antibody-based field-deployable and non-invasive approach. Methods Saliva antibody conversion defined as >= 4-fold increase in IgM, IgA, and/or IgG levels to five SARS-CoV-2 antigens including spike and nucleocapsid constructs was evaluated in 1509 children and 396 adults by high-throughput Luminex assays in samples collected weekly in 22 summer schools and 2 pre-schools in 27 venues in Barcelona, Spain, from June 29th to July 31st, 2020. Results Saliva antibody conversion between two visits over a 5-week period was 3.22% (49/1518) or 2.36% if accounting for potentially cross-reactive antibodies, six times higher than the cumulative infection rate (0.53%) assessed by weekly saliva RT-PCR screening. IgG conversion was higher in adults (2.94%, 11/374) than children (1.31%, 15/1144) (p=0.035), IgG and IgA levels moderately increased with age, and antibodies were higher in females. Most antibody converters increased both IgG and IgA antibodies but some augmented either IgG or IgA, with a faster decay over time for IgA than IgG. Nucleocapsid rather than spike was the main antigen target. Anti-spike antibodies were significantly higher in individuals not reporting symptoms than symptomatic individuals, suggesting a protective role against COVID-19. Conclusion Saliva antibody profiling including three isotypes and multiplexing antigens is a useful and user-friendlier tool for screening pediatric populations to detect low viral load exposures among children, particularly while they are not vaccinated and vulnerable to highly contagious variants, and to recommend public health policies during pandemics.
Filiaciones:
Dobaño C:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain.
CIBER de Enfermedades Infecciosas, Madrid, Spain.
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Alonso S:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Fernández de Sevilla-Estrach M:
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues, Barcelona, Spain
Vidal M:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Jiménez A:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
:
Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues, Barcelona, Spain
Jairoce C:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Melé Casas M:
Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues, Barcelona, Spain
Rubio R:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
:
Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues, Barcelona, Spain
Ruiz-Olalla G:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Girona M:
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Paediatric Intensive Care Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain
Barrios D:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Santano R:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Mitchell RA:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Puyol L:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Mayer L:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Chi J:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Rodrigo Melero N:
Biomolecular Screening and Protein Technologies Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
Carolis C:
Biomolecular Screening and Protein Technologies Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
:
Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Universitat de Barcelona, Barcelona, Spain
Bonet-Carne E:
Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Universitat de Barcelona, Barcelona, Spain
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Universitat Politècnica de Catalunya, BarcelonaTech, Barcelona, Spain
Claverol J:
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Fundació Sant Joan de Déu, Barcelona, Spain
Cubells M:
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Fundació Sant Joan de Déu, Barcelona, Spain
Fortuny-Guasch C:
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
Fumadó V:
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain
Jou-Munoz C:
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Department of Pathology and Biobank Hospital Sant Joan de Déu, Barcelona, Spain
CIBERER, Instituto de Salud Carlos III, Barcelona, Spain
Munoz-Almagro C:
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Department of Medicine, Universitat Internacional de Catalunya, Barcelona, Spain
Molecular Microbiology Department, Hospital Sant Joan de Deu, Esplugues, Barcelona, Spain
Izquierdo L:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
CIBER de Enfermedades Infecciosas, Madrid, Spain
Bassat Q:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues, Barcelona, Spain
Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique
ICREA, Pg. Lluís Companys 23, 08010, Barcelona, Spain
Gratacós E:
Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Universitat de Barcelona, Barcelona, Spain
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Center for Biomedical Research on Rare Diseases (CIBER-ER), Madrid, Spain
Aguilar R:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
García-García JJ:
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Institut de Recerca Sant Joan de Deu, Esplugues, Barcelona, Spain
Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues, Barcelona, Spain
Moncunill G:
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Catalonia, Spain
CIBER de Enfermedades Infecciosas, Madrid, Spain
Jordán-García I:
Institut de Recerca Sant Joan de Déu, Esplugues, Barcelona, Spain.
Paediatric Intensive Care Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.
Green Published, Green Submitted, gold
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