Altered brain responses to specific negative emotions in schizophrenia
Por:
Garcia-Leon MA, Fuentes-Claramonte P, Valiente-Gómez A, Natividad C, Salgado-Pineda P, Gomar JJ, Guerrero-Pedraza A, Portillo F, Ortiz-Gil J, Alonso-Lana S, Maristany M, Raduà J, Salvador R, Sarró S and Pomarol-Clotet E
Publicada:
1 nov 2021
Ahead of Print:
1 nov 2021
Resumen:
Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questioned for not entailing an appropriate stimulus to study emotional processing. This highlights the importance of investigating emotional processing abnormalities using evocative stimuli. For the first time, we have studied the brain responses to scenic stimuli in patients with schizophrenia. We selected scenes from the IAPS that elicit fear, disgust, happiness, and sadness. Twenty-six patients with schizophrenia and thirty age-, sex-and premorbid IQ-matched healthy controls were included. Behavioral task results show that patients tended to misclassify disgust and sadness as fear. Brain responses in patients were different from controls in images eliciting disgust and fear. In response to disgust images, patients hyperactivated the right temporal cortex, which was not activated by the controls. With fear images, hyperactivation was observed in brain regions involved in fear processing, including midline regions from the medial frontal cortex to the anterior cingulate cortex, the superior frontal gyrus, inferior and superior temporal cortex, and visual areas. These results suggest that schizophrenia is characterized by hyper-responsivity to stimuli evoking high-arousal, negative emotions, and a bias towards fear in emotion recognition.
Filiaciones:
Garcia-Leon MA:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Fuentes-Claramonte P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Valiente-Gómez A:
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Natividad C:
Hospital Mare de Déu de la Mercè, Barcelona, Spain
Salgado-Pineda P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Gomar JJ:
Litwin-Zucker Alzheimer's Disease Center, Feinstein Institute, Manhassett, NY, USA
Guerrero-Pedraza A:
Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain
Portillo F:
Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain
Ortiz-Gil J:
General Hospital of Granollers, Barcelona, Spain
Alonso-Lana S:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC), Barcelona, Spain
Maristany M:
Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain
Raduà J:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Imaging of Mood- and Anxiety-Related Disorders(IMARD) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Early Psychosis: Interventions and Clinical-Detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King College London, London, UK
Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Salvador R:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Sarró S:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
Pomarol-Clotet E:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Electronic address:
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